ArticleScientific reports2018
Serum metabolite profile associated with incident type 2 diabetes in Koreans: findings from the Korean Genome and Epidemiology Study.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Metabolomics and Type 2 Diabetes Risk: An Updated Systematic Review and Meta-analysis of Prospective Cohort Studies.Diabetes care · 2022Pooled it
- Choline status and related health outcomes in humans: A scoping review.Nutrition and health · 2026Article
- Plasma 4-Hydroxyproline Levels Are Associated with Diabetes in Chinese Adults: A Cross-Sectional Analysis.Metabolites · 2026Article
- Hyperpathway: visualizing organization of pathway-molecule enriched interactions in omics studies via hyperbolic bipartite network embedding.NPJ systems biology and applications · 2026Article
- From chemical characterization to functional validation: Screening of anti-hyperglycemic components and their action mechanisms in differentially fermented teas.Food chemistry: X · 2026Article
- Effects of short-term exercise on plasma metabolic and lipidomic profiles of individuals with type 2 diabetes.Experimental physiology · 2026Article
- Activated carbon ameliorates type 2 diabetes via metabolic remodeling of the gut microbiota.Microbiology spectrum · 2025Article
- Longitudinal Cohort Study of Metabolomic Markers Associated With Type 2 Diabetes Risk in Korean Adults.Chronic diseases and translational medicine · 2025Article
- Metabolomics and nutrient intake reveal metabolite-nutrient interactions in metabolic syndrome: insights from the Korean Genome and Epidemiology Study.Nutrition journal · 2025Article
- Advances in Metabolomics: A Comprehensive Review of Type 2 Diabetes and Cardiovascular Disease Interactions.International journal of molecular sciences · 2025Review
- Clustering-Based Identification of BMI-Associated Metabolites with Mechanistic Insights from Network Analysis in Korean Men.Metabolites · 2025Article
- Metabolite, Biochemical, and Dietary Intake Alterations Associated with Lifestyle Interventions in Obese and Overweight Malaysian Women.Nutrients · 2024Article
- Ten metabolites-based algorithm predicts the future development of type 2 diabetes in Chinese.Journal of advanced research · 2024Article
- Characterizing poorly controlled type 2 diabetes usingMetabolomics : Official journal of the Metabolomic Society · 2024Article
- Metabolomics and Lipidomics Analyses Aid Model Classification of Type 2 Diabetes in Non-Human Primates.Metabolites · 2024Article
- The clinical relevance of a polygenic risk score for type 2 diabetes mellitus in the Korean population.Scientific reports · 2024Article
- Article
- Exploring the Interactions between Obesity and Diabetes: Implications for Understanding Metabolic Dysregulation in a Saudi Arabian Adult Population.Journal of proteome research · 2024Article
- Metabolomic signatures of ideal cardiovascular health in black adults.Scientific reports · 2024Article
- Machine learning for predicting diabetic metabolism in the Indian population using polar metabolomic and lipidomic features.Metabolomics : Official journal of the Metabolomic Society · 2023Article
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Authors and funding
5 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The identification of metabolic alterations in type 2 diabetes (T2D) is useful for elucidating the pathophysiology of the disease and in classifying high-risk individuals. In this study, we prospectively examined the associations between serum metabolites and T2D risk in a Korean community-based cohort (the Ansan-Ansung cohort). Data were obtained from 1,939 participants with available metabolic profiles and without diabetes, cardiovascular disease, or cancer at baseline. The acylcarnitine, amino acid, amine, and phospholipid levels in fasting serum samples were analyzed by targeted metabolomics. During the 8-year follow-up period, we identified 282 cases of incident T2D. Of all metabolites measured, 22 were significantly associated with T2D risk. Specifically, serum levels of alanine, arginine, isoleucine, proline, tyrosine, valine, hexose and five phosphatidylcholine diacyls were positively associated with T2D risk, whereas lyso-phosphatidylcholine acyl C17:0 and C18:2 and other glycerophospholipids were negatively associated with T2D risk. The associated metabolites were further correlated with T2D-relevant risk factors such as insulin resistance and triglyceride indices. In addition, a healthier diet (as measured by the modified recommended food score) was independently associated with T2D risk. Alterations of metabolites such as amino acids and choline-containing phospholipids appear to be associated with T2D risk in Korean adults.
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