Evidence map›Paper›PMID 29844431›Full record

ArticleScientific reports2018

Excitation and injury of adult ventricular cardiomyocytes by nano- to millisecond electric shocks.

Iurii Semenov, Sergey Grigoryev, Johanna U Neuber, Christian W Zemlin, Olga N Pakhomova, Maura Casciola, Andrei G Pakhomov

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 51 citations in OpenAlex.

  1. Review
  2. Precise mimicry of physiological CaBioengineering & translational medicine · 2026
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  4. Impact of pulse duration on cardiac electroporation: nanosecond pulses enhance cardiomyocyte selectivity and promote a Raman-detected shift towards apoptotic cell death.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
  5. Article
  6. Extracellular Kir2.1Circulation research · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Extracellular cysteine disulfide bond break at Cys122 disrupts PIPbioRxiv : the preprint server for biology · 2023
    Article
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  15. Article
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  19. Review
  20. HumanFrontiers in physiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Iurii SemenovFrank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA, 23508, USA.
Sergey GrigoryevFrank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA, 23508, USA.
Johanna U NeuberFrank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA, 23508, USA.
Christian W ZemlinFrank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA, 23508, USA.
Olga N PakhomovaFrank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA, 23508, USA.
Maura CasciolaFrank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA, 23508, USA.
Andrei G PakhomovFrank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA, 23508, USA. apakhomo@odu.edu.
Old Dominion University · US

Funding

Low Energy Defibrillation with Nanosecond Pulsed Electric FieldR01HL128381 · NHLBI · OLD DOMINION UNIVERSITY · PI PAKHOMOV, ANDREI G · 2015 to 2018
$1.5M
NHLBI NIH HHS R01 HL128381
6 · The paper itself

Abstract

Intense electric shocks of nanosecond (ns) duration can become a new modality for more efficient but safer defibrillation. We extended strength-duration curves for excitation of cardiomyocytes down to 200 ns, and compared electroporative damage by proportionally more intense shocks of different duration. Enzymatically isolated murine, rabbit, and swine adult ventricular cardiomyocytes (VCM) were loaded with a Ca

Indexed as

Electric StimulationAnimalsCalciumCells, CulturedElectroporationFemaleHeart VentriclesMiceMice, Inbred DBAMyocytes, CardiacRabbitsSwineCalcium

Identifiers

PMID29844431
PMCPMC5974370
OpenAlexW2805517520

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.