ArticleScientific reports2018
Rate and Temporal Coding Mechanisms in the Anterior Cingulate Cortex for Pain Anticipation.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Neuropathic Mechanisms in Phantom Pain: A Review of Pain Pathways and Peripheral Localization.Current neurology and neuroscience reports · 2026Review
- Decreases in the sustained firing capacity of layer 2/3 pyramidal neurons in the anterior cingulate cortex of aged rats.Frontiers in aging neuroscience · 2026Article
- Integrating Telemedicine and Embodied Virtual Reality: A Novel Functional Training Intervention for Chronic Shoulder Pain.Journal of medical extended reality · 2025Article
- Effects of Embodiment in Virtual Reality for Treatment of Chronic Pain: Pilot Open-Label Study.JMIR formative research · 2024Article
- Oxytocin Modulation in Mindfulness-Based Pain Management for Chronic Pain.Life (Basel, Switzerland) · 2024Article
- Article
- Review
- Temporal pain processing in the primary somatosensory cortex and anterior cingulate cortex.Molecular brain · 2023Article
- Interhemispheric neural characteristics of noxious mechano-nociceptive stimulation in the anterior cingulate cortex.Frontiers in neural circuits · 2023Article
- Predictive coding models for pain perception.Journal of computational neuroscience · 2021Article
- The Energy Homeostasis Principle: A Naturalistic Approach to Explain the Emergence of Behavior.Frontiers in systems neuroscience · 2021Article
- Detecting acute pain signals from human EEG.Journal of neuroscience methods · 2021Article
- Association between Chronic Pain and Alterations in the Mesolimbic Dopaminergic System.Brain sciences · 2020Review
- Embodiment in Virtual Reality for the Treatment of Chronic Low Back Pain: A Case Series.Journal of pain research · 2020Article
- Central network changes in patients with advanced monocular blindness: A voxel-based morphometric study.Brain and behavior · 2019Article
- A Predictive Coding Model for Evoked and Spontaneous Pain Perception.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2019Article
- The role of hedonics in the Human Affectome.Neuroscience and biobehavioral reviews · 2019Review
- Ensembles of change-point detectors: implications for real-time BMI applications.Journal of computational neuroscience · 2019Article
- Cortical Pain Processing in the Rat Anterior Cingulate Cortex and Primary Somatosensory Cortex.Frontiers in cellular neuroscience · 2019Article
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Authors and funding
6 authors.
Funding
Abstract
Pain is a complex sensory and affective experience. Through its anticipation, animals can learn to avoid pain. Much is known about passive avoidance during a painful event; however, less is known about active pain avoidance. The anterior cingulate cortex (ACC) is a critical hub for affective pain processing. However, there is currently no mechanism that links ACC activities at the cellular level with behavioral anticipation or avoidance. Here we asked whether distinct populations of neurons in the ACC can encode information for pain anticipation. We used tetrodes to record from ACC neurons during a conditioning assay to train rats to avoid pain. We found that in rats that successfully avoid acute pain episodes, neurons that responded to pain shifted their firing rates to an earlier time, whereas neurons that responded to the anticipation of pain increased their firing rates prior to noxious stimulation. Furthermore, we found a selected group of neurons that shifted their firing from a pain-tuned response to an anticipatory response. Unsupervised learning analysis of ensemble spike activity indicates that temporal spiking patterns of ACC neurons can indeed predict the onset of pain avoidance. These results suggest rate and temporal coding schemes in the ACC for pain avoidance.
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