Evidence map›Paper›PMID 29844412›Full record

ArticleScientific reports2018

Mitochondrial imaging in live or fixed tissues using a luminescent iridium complex.

Alexandra Sorvina, Christie A Bader, Jack R T Darby, Mitchell C Lock, Jia Yin Soo, Ian R D Johnson, Chiara Caporale, Nicolas H Voelcker, Stefano Stagni, Massimiliano Massi and 3 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 38 citations in OpenAlex.

  1. White matter lipidome alterations in the schizophrenia brain.Schizophrenia (Heidelberg, Germany) · 2024
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  11. Following the Dynamism of the Mitochondrial Network in T Cells.Methods in molecular biology (Clifton, N.J.) · 2021
    Article
  12. International journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Alexandra SorvinaMechanisms in Cell Biology and Disease Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, 5001, Australia.
Christie A BaderMechanisms in Cell Biology and Disease Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, 5001, Australia.ORCID 0000-0002-4653-912X
Jack R T DarbyEarly Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, 5001, Australia.ORCID 0000-0001-7114-3920
Mitchell C LockEarly Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, 5001, Australia.
Jia Yin SooEarly Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, 5001, Australia.
Ian R D JohnsonMechanisms in Cell Biology and Disease Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, 5001, Australia.ORCID 0000-0001-7875-3510
Chiara CaporaleDepartment of Chemistry and Curtin Institute for Functional Molecules and Interfaces, Curtin University, Bentley, Western Australia, 6102, Australia.
Nicolas H VoelckerFuture Industries Institute, University of South Australia, Adelaide, South Australia, 5095, Australia.ORCID 0000-0002-1536-7804
Stefano StagniDepartment of Industrial Chemistry "Toso Montanari", University of Bologna, Bologna, I-40136, Italy.
Massimiliano MassiMechanisms in Cell Biology and Disease Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, 5001, Australia.
Janna L MorrisonEarly Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, 5001, Australia.ORCID 0000-0002-8602-8519
Sally E PlushMechanisms in Cell Biology and Disease Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, 5001, Australia. Sally.Plush@unisa.edu.au.
Douglas A BrooksMechanisms in Cell Biology and Disease Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, 5001, Australia. Doug.Brooks@unisa.edu.au.
University of South Australia · AUCurtin University · AUUniversity of Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial morphology is important for the function of this critical organelle and, accordingly, altered mitochondrial structure is exhibited in many pathologies. Imaging of mitochondria can therefore provide important information about disease presence and progression. However, mitochondrial imaging is currently limited by the availability of agents that have the capacity to image mitochondrial morphology in both live and fixed samples. This can be particularly problematic in clinical studies or large, multi-centre cohort studies, where tissue archiving by fixation is often more practical. We previously reported the synthesis of an iridium coordination complex [Ir(ppy)

Indexed as

AnimalsCell LineCell SurvivalCoordination ComplexesFemaleHistocytological Preparation TechniquesIridiumLuminescenceLuminescent AgentsMicroscopy, ConfocalMitochondriaOptical ImagingRatsSheepTissue FixationCoordination ComplexesIridiumLuminescent Agents

Identifiers

PMID29844412
PMCPMC5974328
OpenAlexW2806713295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.