ArticleScientific reports2018
Habituation of phase-locked local field potentials and gamma-band oscillations recorded from the human insula.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- The Human Insula Reimagined: Single Neurons Respond to Simple Sounds during Passive Listening.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- EEG oscillations reveal neuroplastic changes in pain processing associated with long-term meditation.Scientific reports · 2025Article
- Human insula neurons respond to simple sounds during passive listening.bioRxiv : the preprint server for biology · 2025Article
- Primary somatosensory cortex oscillations in trigeminal neuralgia: laser-evoked signatures and their potential relevance to microvascular decompression.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Advances and challenges in neuroimaging-based pain biomarkers.Cell reports. Medicine · 2024Review
- Entangled brains and the experience of pains.Frontiers in psychology · 2024Review
- Interindividual variability and individual stability of pain- and touch-related neuronal gamma oscillations.Journal of neurophysiology · 2023Article
- Brain Responses to Surprising Stimulus Offsets: Phenomenology and Functional Significance.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Insular responses to transient painful and non-painful thermal and mechanical spinothalamic stimuli recorded using intracerebral EEG.Scientific reports · 2020Article
- Involvement of Frontal Functions in Pain Tolerance in Aging: Evidence From Neuropsychological Assessments and Gamma-Band Oscillations.Frontiers in aging neuroscience · 2020Article
- Imaging Clinically Relevant Pain States Using Arterial Spin Labeling.Pain reports · 2019Article
- Distinct patterns of brain activity mediate perceptual and motor and autonomic responses to noxious stimuli.Nature communications · 2018Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salient nociceptive and non-nociceptive stimuli elicit low-frequency local field potentials (LFPs) in the human insula. Nociceptive stimuli also elicit insular gamma-band oscillations (GBOs), possibly preferential for thermonociception, which have been suggested to reflect the intensity of perceived pain. To shed light on the functional significance of these two responses, we investigated whether they would be modulated by stimulation intensity and temporal expectation - two factors contributing to stimulus saliency. Insular activity was recorded from 8 depth electrodes (41 contacts) implanted in the left insula of 6 patients investigated for epilepsy. Thermonociceptive, vibrotactile, and auditory stimuli were delivered using two intensities. To investigate the effects of temporal expectation, the stimuli were delivered in trains of three identical stimuli (S1-S2-S3) separated by a constant 1-s interval. Stimulation intensity affected intensity of perception, the magnitude of low-frequency LFPs, and the magnitude of nociceptive GBOs. Stimulus repetition did not affect perception. In contrast, both low-frequency LFPs and nociceptive GBOs showed a marked habituation of the responses to S2 and S3 as compared to S1 and, hence, a dissociation with intensity of perception. Most importantly, although insular nociceptive GBOs appear to be preferential for thermonociception, they cannot be considered as a correlate of perceived pain.
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