ArticleNature communications2018
mTOR coordinates transcriptional programs and mitochondrial metabolism of activated T
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 133 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
133citing papers in PubMed, 1 pooled it
10.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
133 citing papers in PubMed, 1 synthesis or guideline pooled it, 186 citations in OpenAlex.
- Regulatory T lymphocytes/Th17 lymphocytes imbalance in autism spectrum disorders: evidence from a meta-analysis.Molecular autism · 2021Pooled it
- Interferon regulatory factors orchestrate CD8International journal of molecular medicine · 2026Review
- Boosting T cell antioxidant capacity: A strategic approach to overcome immunosuppression in solid tumors.Redox biology · 2026Review
- Bap1-mediated deubiquitination determines immune tolerance and anti-tumor immunity via modulating eTreg cell differentiation and ferroptosis.Cell death and differentiation · 2026Article
- The Glucose Transporter GLUT3 Controls Regulatory T Cell Function.European journal of immunology · 2026Article
- Regulatory T cells as a potential treatment for autoimmune inflammatory rheumatic and musculoskeletal diseases.Clinical rheumatology · 2026Review
- Next-Generation regulatory T cell therapies: Translational considerations for inflammatory bowel disease.Human immunology · 2026Review
- Hypoxia regulates Th17/Treg balance by altering chromatin accessibility and gene expression.The FEBS journal · 2026Article
- Tumor-immune metabolic tug-of-war: from immune escape to targeting metabolic rewiring in cancer therapy.Frontiers in cell and developmental biology · 2026Review
- Immunometabolic reprogramming in sepsis: mechanisms, clinical endotypes, and therapeutic opportunities.Frontiers in immunology · 2026Review
- Mitochondrial Transcription Factor A Deficiency in T Cells Leads to Activation of the Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase/Stimulator of Interferon Genes Pathway and Production of Autoantibodies in Mice.Journal of immunology research · 2026Article
- Spatial Treg niches and the therapeutic reprogramming of tumour tolerance in cancer.Frontiers in cell and developmental biology · 2026Review
- Cellular metabolism in Th9, Th17, and Treg cell differentiation.International immunology · 2025Review
- Pioglitazone reduces hepatic α-1 antitrypsin accumulation through autophagy and AMPK activation in α-1 antitrypsin-deficient mice.American journal of physiology. Gastrointestinal and liver physiology · 2025Article
- Mitochondrial and lysosomal signaling orchestrates heterogeneous metabolic states of regulatory T cells.Science immunology · 2025Article
- Mitochondria and lysosomes in T cell immunometabolism.Trends in immunology · 2025Review
- Regulatory T cells in the tumour microenvironment.Nature reviews. Cancer · 2025Review
- BI-5756 Reduces Graft-Versus-Host Disease Through CB1-Mediated Treg Upregulation.Molecules (Basel, Switzerland) · 2025Article
- Immune regulation by the SUMO family.Nature reviews. Immunology · 2025Review
- A new method to measure cell metabolism of rare cells in vivo reveals a high oxidative phosphorylation dependence of lung T cells.Immunology and cell biology · 2025Article
73 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Nicole M ChapmanDepartment of Immunology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 351, Memphis, TN, 38105, USA.
Hu ZengDepartment of Immunology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 351, Memphis, TN, 38105, USA.ORCID http://orcid.org/0000-0002-9909-7732
Thanh-Long M NguyenDepartment of Immunology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 351, Memphis, TN, 38105, USA.
Yanyan WangDepartment of Immunology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 351, Memphis, TN, 38105, USA.
Peter VogelDepartment of Pathology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 250, Memphis, TN, 38105, USA.ORCID http://orcid.org/0000-0002-7535-0545
Yogesh DhunganaDepartment of Immunology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 351, Memphis, TN, 38105, USA.
Xiaojing LiuDepartment of Pharmacology & Cancer Biology, Duke University School of Medicine, Levine Science Research Center C266, Box 3813, Durham, NC, 27710, USA.
Geoffrey NealeHartwell Center for Bioinformatics and Biotechnology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 312, Memphis, TN, 38105, USA.ORCID http://orcid.org/0000-0003-3776-0858
Jason W LocasaleDepartment of Pharmacology & Cancer Biology, Duke University School of Medicine, Levine Science Research Center C266, Box 3813, Durham, NC, 27710, USA.ORCID http://orcid.org/0000-0002-7766-3502
Hongbo ChiDepartment of Immunology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 351, Memphis, TN, 38105, USA. hongbo.chi@stjude.org.
St. Jude Children's Research Hospital · USDuke University · US
Funding
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9MThe MKP-1/p38 axis: coordinating innate and adaptive immunityR01NS064599 · NINDS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHI, HONGBO · 2008 to 2018
$3.7MMetabolic checkpoint in dendritic cell subsets and adaptive immunityR37AI105887 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Hongbo Chi · 2019 to 2026
$3.6MMetabolic checkpoint in TH17 cell differentiationR01AI105887 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHI, HONGBO · 2014 to 2018
$2.2MmTOR signaling in T cell quiescenceR01AI101407 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHI, HONGBO · 2013 to 2017
$2.2MTsc1/mTOR axis in immune homeostasis and tumorigenesisR01CA176624 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHI, HONGBO · 2014 to 2018
$1.9MMetabolic reprogramming of Tregs in tumor immunityR01CA221290 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHI, HONGBO · 2017 to 2020
$1.6MData commons for 'omic, microscopy and analysis core facilitiesS10OD018164 · OD · DUKE UNIVERSITY · PI WRAY, GREGORY A. · 2014 to 2014
$598kNCI NIH HHS R01 CA176624NCI NIH HHS R01 CA221290NIAID NIH HHS R01 AI101407NIAID NIH HHS R01 AI105887NIAID NIH HHS R37 AI105887NINDS NIH HHS R01 NS064599
Abstract
Regulatory T (T
Indexed as
AnimalsCells, CulturedDNA-Binding ProteinsFemaleHigh Mobility Group ProteinsHomeostasisHumansImmune ToleranceInterferon Regulatory Factor-4Interferon Regulatory FactorsLymphocyte ActivationMaleMiceMice, Inbred C57BLMice, KnockoutMitochondriaDNA-Binding ProteinsHigh Mobility Group ProteinsInterferon Regulatory Factor-4Interferon Regulatory FactorsmTOR protein, mouseTfam protein, mouseTOR Serine-Threonine Kinases
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.