Evidence map›Paper›PMID 29844327›Full record

ArticleScientific reports2018

Interferon-gamma drives programmed death-ligand 1 expression on islet β cells to limit T cell function during autoimmune diabetes.

Kevin C Osum, Adam L Burrack, Tijana Martinov, Nathanael L Sahli, Jason S Mitchell, Christopher G Tucker, Kristen E Pauken, Klearchos Papas, Balamurugan Appakalai, Justin A Spanier and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kevin C OsumDepartment of Medicine, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.
Adam L BurrackDepartment of Medicine, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.
Tijana MartinovDepartment of Medicine, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.
Nathanael L SahliDepartment of Medicine, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.
Jason S MitchellDepartment of Medicine, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.
Christopher G TuckerDepartment of Medicine, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.
Kristen E PaukenDepartment of Medicine, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.
Klearchos PapasDepartment of Surgery, University of Arizona, Tucson, AZ, USA.
Balamurugan AppakalaiDepartment of Surgery, University of Louisville, Louisville, KY, USA.
Justin A SpanierDepartment of Medicine, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA.
Brian T FifeDepartment of Medicine, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, 55455, USA. bfife@umn.edu.ORCID 0000-0001-9826-5637

Funding

Type I interferons in tolerance in the steady stateP01AI035296 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI HOGQUIST, KRISTIN A. · 1993 to 2023
$31.1M
IMMUNOLOGY TRAINING PROGRAMT32AI007313 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Carla Rothlin · 1989 to 2026
$5.7M
TRAINING GRANT IN DIABETES, ENDOCRINOLOGY, &METABOLISMT32DK007203 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LISA Senye CHOW, Douglas G Mashek · 1986 to 2026
$4.3M
Multiplex immune analysis of antigen specific CD4+ T cells in autoimmune diabetesU24AI118635 · NIAID · UNIVERSITY OF MINNESOTA · PI FIFE, BRIAN T · 2015 to 2019
$2.3M
Mechanisms of immune tolerance in autoimmune diabetesR01AI106791 · NIAID · UNIVERSITY OF MINNESOTA · PI FIFE, BRIAN T · 2014 to 2018
$1.9M
NIAID NIH HHS P01 AI035296NIAID NIH HHS R01 AI106791NIAID NIH HHS T32 AI007313NIAID NIH HHS U24 AI118635NIDDK NIH HHS T32 DK007203
6 · The paper itself

Abstract

Type 1 diabetes is caused by autoreactive T cell-mediated β cell destruction. Even though co-inhibitory receptor programmed death-1 (PD-1) restrains autoimmunity, the expression and regulation of its cognate ligands on β cell remains unknown. Here, we interrogated β cell-intrinsic programmed death ligand-1 (PD-L1) expression in mouse and human islets. We measured a significant increase in the level of PD-L1 surface expression and the frequency of PD-L1

Indexed as

AnimalsB7-H1 AntigenDiabetes Mellitus, Type 1FemaleHumansInterferon-gammaIslets of LangerhansMiceMice, Inbred NODT-LymphocytesB7-H1 AntigenCd274 protein, mouseInterferon-gamma

Identifiers

PMID29844327
PMCPMC5974126

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.