Evidence map›Paper›PMID 29844310›Full record

ArticleNature communications2018

Budding-like division of all-aqueous emulsion droplets modulated by networks of protein nanofibrils.

Yang Song, Thomas C T Michaels, Qingming Ma, Zhou Liu, Hao Yuan, Shuichi Takayama, Tuomas P J Knowles, Ho Cheung Shum

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 102 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Dramatic droplet deformation through interfacial particles jamming.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Liquid-embedded (bio)printing of alginate-free, standalone, ultrafine, and ultrathin-walled cannular structures.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  11. Article
  12. Growth, replication and division enable evolution of coacervate protocells.Chemical communications (Cambridge, England) · 2022
    Review
  13. Article
  14. Article
  15. Roe-inspired stem cell microcapsules for inflammatory bowel disease treatment.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

Yang SongDepartment of Mechanical Engineering, The University of Hong Kong, Pokfulam, 999077, Hong Kong.ORCID http://orcid.org/0000-0002-4914-8490
Thomas C T MichaelsDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Qingming MaDepartment of Mechanical Engineering, The University of Hong Kong, Pokfulam, 999077, Hong Kong.
Zhou LiuDepartment of Mechanical Engineering, The University of Hong Kong, Pokfulam, 999077, Hong Kong.
Hao YuanDepartment of Mechanical Engineering, The University of Hong Kong, Pokfulam, 999077, Hong Kong.
Shuichi TakayamaWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.ORCID http://orcid.org/0000-0002-4385-9080
Tuomas P J KnowlesDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Ho Cheung ShumDepartment of Mechanical Engineering, The University of Hong Kong, Pokfulam, 999077, Hong Kong. ashum@hku.hk.
University of Hong Kong · HKGeorgia Institute of Technology · USHarvard University · USInstitut de Recherche et d’Innovation · FRUniversity of Cambridge · GB

Funding

European Research Council 337969Wellcome Trust
6 · The paper itself

Abstract

Networks of natural protein nanofibrils, such as cytoskeletal filaments, control the shape and the division of cells, yet mimicking this functionality in a synthetic setting has proved challenging. Here, we demonstrate that artificial networks of protein nanofibrils can induce controlled deformation and division of all-aqueous emulsion droplets with budding-like morphologies. We show that this process is driven by the difference in the immersional wetting energy of the nanofibril network, and that both the size and the number of the daughter droplets formed during division can be controlled by modulating the fibril concentration and the chemical properties of the fibril network. Our results demonstrate a route for achieving biomimetic division with synthetic self-assembling fibrils and offer an engineered approach to regulate the morphology of protein gels.

Indexed as

Artificial CellsCell ShapeEmulsionsGelsNanofibersWaterEmulsionsGelsWater

Identifiers

PMID29844310
PMCPMC5974351
OpenAlexW2805498678

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.