ArticleMaterials (Basel, Switzerland)2018
Effects of Build Orientation on Surface Morphology and Bone Cell Activity of Additively Manufactured Ti6Al4V Specimens.
Article in Materials (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 41 citations in OpenAlex.
- Biological Characterization of Ti6Al4V Additively Manufactured Surfaces: Comparison Between Ultrashort Laser Texturing and Conventional Post-Processing.Advanced healthcare materials · 2025Article
- Advanced Ti-Nb-Ta Alloys for Bone Implants with Improved Functionality.Journal of functional biomaterials · 2024Article
- Article
- Effects of Different Titanium Surfaces Created by 3D Printing Methods, Particle Sizes, and Acid Etching on Protein Adsorption and Cell Adhesion, Proliferation, and Differentiation.Bioengineering (Basel, Switzerland) · 2022Article
- Improving the Mechanical Strength of Dental Applications and Lattice Structures SLM Processed.Materials (Basel, Switzerland) · 2020Article
- Effectiveness of Low-Level Laser Therapy during Tooth Movement: A Randomized Clinical Trial.Materials (Basel, Switzerland) · 2019Article
- Effects of Electropolishing on Mechanical Properties and Bio-Corrosion of Ti6Al4V Fabricated by Electron Beam Melting Additive Manufacturing.Materials (Basel, Switzerland) · 2019Article
- Surface properties and bioactivity of TiORoyal Society open science · 2019Article
- Effect of Hydroxyapatite Formation on Titanium Surface with Bone Morphogenetic Protein-2 Loading through Electrochemical Deposition on MG-63 Cells.Materials (Basel, Switzerland) · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Additive manufacturing of lightweight or functional structures by selective laser beam (SLM) or electron beam melting (EBM) is widespread, especially in the field of medical applications. SLM and EBM processes were applied to prepare Ti6Al4V test specimens with different surface orientations (0°, 45° and 90°). Roughness measurements of the surfaces were conducted and cell behavior on these surfaces was analyzed. Hence, human osteoblasts were seeded on test specimens to determine cell viability (metabolic activity, live-dead staining) and gene expression of collagen type 1 (Col1A1), matrix metalloprotease (MMP) 1 and its natural inhibitor, TIMP1, after 3 and 7 days. The surface orientation of specimens during the manufacturing process significantly influenced the roughness. Surface roughness showed significant impact on cellular viability, whereas differences between the time points day 3 and 7 were not found. Collagen type 1 mRNA synthesis rates in human osteoblasts were enhanced with increasing roughness. Both manufacturing techniques further influenced the induction of bone formation process in the cell culture. Moreover, the relationship between osteoblastic collagen type 1 mRNA synthesis rates and specimen orientation during the building process could be characterized by functional formulas. These findings are useful in the designing of biomedical applications and medical devices.
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