ArticleMolecules (Basel, Switzerland)2018
MAO-A Inhibitory Potential of Terpene Constituents from Ginger Rhizomes-A Bioactivity Guided Fractionation.
Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- Comparative analysis of flower volatiles from four Jasminum species growing in Egypt using multivariate analysis.Scientific reports · 2026Article
- Phytoconstituents as Potential Therapeutics against Enzymatic Targets for Neurodegenerative Diseases.Current protein & peptide science · 2026Review
- Neuroprotective Properties of Oleanolic Acid-Computational-Driven Molecular Research Combined with In Vitro and In Vivo Experiments.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Review
- Review of natural compounds for potential psoriasis treatment.Inflammopharmacology · 2023Review
- The Use of Infrared Spectroscopy for the Quantification of Bioactive Compounds in Food: A Review.Molecules (Basel, Switzerland) · 2023Review
- Zebrafish as a robust preclinical platform for screening plant-derived drugs with anticonvulsant properties-a review.Frontiers in molecular neuroscience · 2023Review
- Impact of Thermal Processing on the Composition of Secondary Metabolites of Ginger Rhizome-A Review.Foods (Basel, Switzerland) · 2022Review
- Natural Products Inhibitors of Monoamine Oxidases-Potential New Drug Leads for Neuroprotection, Neurological Disorders, and Neuroblastoma.Molecules (Basel, Switzerland) · 2022Review
- An electron microscopic and biochemical study of the potential protective effect of ginger against Cadmium-induced testicular pathology in rats.Frontiers in physiology · 2022Article
- 6-Gingerol, a Major Constituent ofInternational journal of molecular sciences · 2021Article
- Acetylcholinesterase Inhibitors amongMolecules (Basel, Switzerland) · 2020Article
- Ginger and Testosterone.Biomolecules · 2018Review
- The modulatory role of 6-gingerol-rich portion of ginger on brain oxidative stress, inflammation and neurotransmission in chronic unpredicted mild stress-induced depressed male Wistar rats.Avicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn the search for novel antidepressive drug candidates, bioguided fractionation of nonpolar constituents present in the oleoresin from ginger rhizomes (
methodsHexane extracts from ginger rhizomes were fractionated by using column chromatography (including silica gel impregnated with silver nitrate) and semi-preparative high-performance chromatography. For the activity assessment, an in vitro monoamine oxidase A (MAO-A) inhibition luminescence assay was performed on 10 purified terpenes: 1,8-cineole, α-citronellal, geraniol, β-sesquiphellandrene, γ-terpinen, geranyl acetate, isobornyl acetate, terpinen-4-ol, (
resultsGeraniol and (-)-terpinen-4-ol were found to be the strongest enzyme inhibitors with inhibition of 44.1% and 42.5%, respectively, at a concentration of 125 µg/mL. No differences in the inhibition potential were observed for the different groups of terpenes: sesquiterpenes, monoterpenes, or sesquiterpene alcohols; however, the two most active compounds contained a hydroxyl moiety.
conclusionsTerpene constituents from ginger's extract were found to exhibit moderate inhibitory properties against the MAO-A enzyme in in vitro tests.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.