Evidence map›Paper›PMID 29844241›Full record

ArticleInfection and immunity2018

TPL2 Is a Key Regulator of Intestinal Inflammation in Clostridium difficile Infection.

Yuanguo Wang, Shaohui Wang, Ciaran P Kelly, Hanping Feng, Andrew Greenberg, Xingmin Sun

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Cytotoxic synergism ofWorld journal of gastroenterology · 2023
    Review
  3. Article
  4. Invisible steps for a global endemy: molecular strategies adopted byTherapeutic advances in gastroenterology · 2021
    Review
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Yuanguo Wang *Department of Molecular Medicine, Morsani School of Medicine, University of South Florida, Tampa, Florida, USA.
Shaohui Wang *Department of Molecular Medicine, Morsani School of Medicine, University of South Florida, Tampa, Florida, USA.
Ciaran P KellyDivision of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Hanping FengDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, Maryland, USA.
Andrew GreenbergObesity and Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center, Boston, Massachusetts, USA.
Xingmin SunDepartment of Molecular Medicine, Morsani School of Medicine, University of South Florida, Tampa, Florida, USA sun5@health.usf.edu.
University of South Florida · USHarvard University · USJean Mayer Human Nutrition Research Center on Aging · USTufts University · USUniversity of Maryland, Baltimore · US

Funding

Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI CORKEY, BARBARA E. · 1992 to 2021
$25.0M
Multivalent vaccines against Clostridium difficile infectionR01AI132711 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI Xingmin Sun, Shifeng Wang · 2017 to 2026
$3.3M
Drug-Vitamin Interactions Mediated by the Thiamine Transporter, SLC19A3R01DK108722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GIACOMINI, KATHLEEN M, GREENBERG, ANDREW S · 2017 to 2020
$2.6M
Signaling pathway of TNF-alpha production and Clostridium difficile infection (CDK01DK092352 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI SUN, XINGMIN · 2012 to 2016
$470k
Multivalent Bacillus mucosal vaccines against Clostridium difficile infectionR21AI113470 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI SUN, XINGMIN · 2015 to 2016
$438k
The role of tumor progression locus 2 (TPL2) in the pathogenesis of Clostridium difficile infection (CDI)R03DK112004 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI SUN, XINGMIN · 2017 to 2018
$154k
NIAID NIH HHS R01 AI132711NIAID NIH HHS R21 AI113470NIDDK NIH HHS K01 DK092352NIDDK NIH HHS P30 DK046200NIDDK NIH HHS R01 DK108722NIDDK NIH HHS R03 DK112004
6 · The paper itself

Abstract

Tumor progression locus 2 (TPL2), a serine/threonine protein kinase, is a major inflammatory mediator in immune cells. The predominant inflammatory actions of TPL2 depend on the activation of mitogen-activated protein kinases (MAPK) and the upregulated production of the cytokines tumor necrosis factor alpha (TNF-α) and interleukin 1β (IL-1β) in macrophages and dendritic cells in response to lipopolysaccharide (LPS). Significant increases in TNF-α, IL-6, IL-β, and IL-8 levels in patients with

Indexed as

AnimalsBlotting, WesternCecumClostridium InfectionsColonCytokinesDisease SusceptibilityHumansInflammationMAP Kinase Kinase KinasesMice, Inbred C57BLMice, KnockoutPeroxidaseProto-Oncogene ProteinsSignal TransductionCytokinesMAP3K8 protein, humanMap3k8 protein, mouseMAP Kinase Kinase KinasesPeroxidaseProto-Oncogene ProteinsClostridium difficileinflammationTPL2

Identifiers

PMID29844241
PMCPMC6056850
OpenAlexW2805737684

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.