ArticleProceedings of the National Academy of Sciences of the United States of America2018
How electrostatic networks modulate specificity and stability of collagen.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- De Novo Design of Specific Heterotrimeric Collagen-Like Peptides via Genetic Algorithm.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Efficient secretory expression of type III recombinant human collagen with triple-helical structure in Komagataella phaffii.Applied microbiology and biotechnology · 2025Article
- Around the collagen triple helix: an introduction to studying associated genetic and acquired diseases.Matrix biology : journal of the International Society for Matrix Biology · 2025Review
- Deciphering the folding code of collagens.Nature communications · 2025Article
- Heterotrimeric collagen helix with high specificity of assembly results in a rapid rate of folding.Nature chemistry · 2024Article
- Versatile Self-Assembly of Triblock Peptides into Stable Collagen Mimetic Heterotrimers.International journal of molecular sciences · 2024Article
- Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease.Acta neuropathologica · 2024Article
- Stability of collagen heterotrimer with same charge pattern and different charged residue identities.Biophysical journal · 2023Article
- A recombinant technique for mapping functional sites of heterotrimeric collagen helices: Collagen IV CB3 fragment as a prototype for integrin binding.The Journal of biological chemistry · 2023Article
- Structural Achievability of an NH-π Interaction between Gln and Phe in a Crystal Structure of a Collagen-like Peptide.Biomolecules · 2022Article
- Contrasting Local and Macroscopic Effects of Collagen Hydroxylation.International journal of molecular sciences · 2021Article
- Composition-dependent energetic contribution of complex salt bridges to collagen stability.Biophysical journal · 2021Article
- Predicting the stability of homotrimeric and heterotrimeric collagen helices.Nature chemistry · 2021Article
- Collagen Mimetic Peptides.Bioengineering (Basel, Switzerland) · 2021Review
- Evidence for Quantum Chemical Effects in Receptor-Ligand Binding Between Integrin and Collagen Fragments - A Computational Investigation With an Impact on Tissue Repair, Neurooncolgy and Glycobiology.Frontiers in molecular biosciences · 2021Article
- Modeling Fibrillogenesis of Collagen-Mimetic Molecules.Biophysical journal · 2020Article
- Recent trends in protein and peptide-based biomaterials for advanced drug delivery.Advanced drug delivery reviews · 2020Review
- Highly Water-Preserving Zwitterionic Betaine-Incorporated Collagen Sponges With Anti-oxidation and Anti-inflammation for Wound Regeneration.Frontiers in cell and developmental biology · 2020Article
- Temperature-controlled electrospray ionization mass spectrometry as a tool to study collagen homo- and heterotrimers.Chemical science · 2019Article
- A cysteine-based molecular code informs collagen C-propeptide assembly.Nature communications · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One-quarter of the 28 types of natural collagen exist as heterotrimers. The oligomerization state of collagen affects the structure and mechanics of the extracellular matrix, providing essential cues to modulate biological and pathological processes. A lack of high-resolution structural information limits our mechanistic understanding of collagen heterospecific self-assembly. Here, the 1.77-Å resolution structure of a synthetic heterotrimer demonstrates the balance of intermolecular electrostatics and hydrogen bonding that affects collagen stability and heterospecificity of assembly. Atomistic simulations and mutagenesis based on the solved structure are used to explore the contributions of specific interactions to energetics. A predictive model of collagen stability and specificity is developed for engineering novel collagen structures.
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