Evidence map›Paper›PMID 29844129›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2018

Phase Ib Study of Binimetinib with Paclitaxel in Patients with Platinum-Resistant Ovarian Cancer: Final Results, Potential Biomarkers, and Extreme Responders.

Rachel N Grisham, Kathleen N Moore, Michael S Gordon, Wael Harb, Gwendolyn Cody, Darragh F Halpenny, Vicky Makker, Carol A Aghajanian

Open access · greenAbstract readClinical Trial, Phase IMulticenter Study
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Mucocutaneous toxicities from MEK inhibitors: a scoping review of the literature.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Article
  10. Targeting BRAF pathway in low-grade serous ovarian cancer.Journal of gynecologic oncology · 2024
    Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Low-grade Serous Tumors: Are We Making Progress?Current oncology reports · 2020
    Review
  16. Review
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Rachel N GrishamGynecologic Medical Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. grishamr@mskcc.org.
Kathleen N MooreStephenson Oklahoma Cancer Center, University of Oklahoma, Oklahoma City, Oklahoma.
Michael S GordonPinnacle Oncology Hematology, Scottsdale, Arizona.
Wael HarbHorizon Oncology Research, Inc., Lafayette, Indiana.
Gwendolyn CodyNew York University School of Medicine, New York, New York.
Darragh F HalpennyDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Vicky MakkerGynecologic Medical Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Carol A AghajanianGynecologic Medical Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Memorial Sloan Kettering Cancer Center · USHorizon Oncology Center · USNew York University · USOklahoma State University Oklahoma City · USPinnacle Oncology Hematology · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAgedAntineoplastic Combined Chemotherapy ProtocolsBenzimidazolesBiomarkersCombined Modality TherapyDrug Resistance, NeoplasmFemaleHumansMaximum Tolerated DoseMiddle AgedNeoplasm StagingOvarian NeoplasmsPaclitaxelPlatinum CompoundsProtein Kinase InhibitorsBenzimidazolesbinimetinibBiomarkersPaclitaxelPlatinum CompoundsProtein Kinase Inhibitors

Identifiers

PMID29844129
PMCPMC6616528
OpenAlexW2805386901

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.