Evidence map›Paper›PMID 29844112›Full record

ArticlemBio2018

Fungal Isocyanide Synthases and Xanthocillin Biosynthesis in Aspergillus fumigatus.

Fang Yun Lim, Tae Hyung Won, Nicholas Raffa, Joshua A Baccile, Jen Wisecaver, Antonis Rokas, Frank C Schroeder, Nancy P Keller

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 81 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Identification of Natural Isonitriles Through Ligation to an Azomethine Imine Probe.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Copper-chelating natural products.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025
    Review
  13. The proteomic response ofmicroLife · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. A Timeline of Biosynthetic Gene Cluster Discovery inJournal of fungi (Basel, Switzerland) · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Fang Yun Lim *Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Tae Hyung Won *Boyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York, USA.
Nicholas RaffaDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Joshua A BaccileBoyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York, USA.
Jen WisecaverDepartment of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA.
Antonis RokasDepartment of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA.ORCID 0000-0002-7248-6551
Frank C SchroederBoyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York, USA.
Nancy P KellerDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA npkeller@wisc.edu.
Cornell University · USUniversity of Wisconsin–Madison · USVanderbilt University · US

Funding

BIOTECHNOLOGY TRAINING PROGRAMT32GM008349 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI FOX, BRIAN G · 1989 to 2019
$22.5M
CHEMISTRY OF BIOLOGICAL SYSTEMST32GM008500 · NIGMS · CORNELL UNIVERSITY ITHACA · PI LIN, HENING · 1996 to 2020
$5.4M
Comprehensive analysis of NRPS-derived metabolomes of three Aspergillus speciesR01GM112739 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI KELLER, NANCY P · 2015 to 2023
$2.8M
NIGMS NIH HHS R01 GM112739NIGMS NIH HHS T32 GM008349NIGMS NIH HHS T32 GM008500
6 · The paper itself

Abstract

Microbial secondary metabolites, including isocyanide moieties, have been extensively mined for their repertoire of bioactive properties. Although the first naturally occurring isocyanide (xanthocillin) was isolated from the fungus

Indexed as

Aspergillus fumigatusBiosynthetic PathwaysButadienesCyanidesFungal ProteinsMultigene FamilyPeptide SynthasesPhenolsPhylogenyButadienesCyanidesFungal Proteinsnon-ribosomal peptide synthasePeptide SynthasesPhenolsxantocillinAspergillus fumigatuscopperisocyanide synthasemelanocinxanthocillin

Identifiers

PMID29844112
PMCPMC5974471
OpenAlexW2807035908

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.