Evidence map›Paper›PMID 29844022›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

A Central Extended Amygdala Circuit That Modulates Anxiety.

Sandra Ahrens, Melody V Wu, Alessandro Furlan, Ga-Ram Hwang, Raehum Paik, Haohong Li, Mario A Penzo, Jessica Tollkuhn, Bo Li

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 174 citations in OpenAlex.

  1. Article
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  4. Article
  5. Review
  6. Fear, anxiety, and the extended amygdala-bioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Article
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  11. Review
  12. Article
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  15. Article
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  17. Article
  18. An Honest Reckoning With the Amygdala and Mental Illness.The American journal of psychiatry · 2024
    Review
  19. Article
  20. Article

36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Sandra AhrensCold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724.
Melody V WuCold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724.ORCID 0000-0002-5246-2659
Alessandro FurlanCold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724.
Ga-Ram HwangCold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724.
Raehum PaikCold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724.
Haohong LiCold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724.
Mario A PenzoCold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724.
Jessica TollkuhnCold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724.ORCID 0000-0001-5991-7620
Bo LiCold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724 bli@cshl.edu.ORCID 0000-0002-0154-3088
Cold Spring Harbor Laboratory · US

Funding

Single-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI John Edward Moses · 1987 to 2026
$118.9M
The basal ganglia–habenula circuitry in reward processingR01MH108924 · NIMH · COLD SPRING HARBOR LABORATORY · PI Jessica Tollkuhn · 2015 to 2026
$6.8M
The central amygdala circuits in motivated behaviorsR01MH101214 · NIMH · COLD SPRING HARBOR LABORATORY · PI VAN AELST, LINDA · 2014 to 2024
$6.3M
Multiplex imaging of neuronal activity and signaling dynamics underlying learning in discrete amygdala circuits of behaving mice.R01NS104944 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI LI, BO, MAO, TIANYI · 2018 to 2022
$5.0M
NCI NIH HHS P30 CA045508NIMH NIH HHS R01 MH101214NIMH NIH HHS R01 MH108924NINDS NIH HHS R01 NS104944
6 · The paper itself

Abstract

Both the amygdala and the bed nucleus of the stria terminalis (BNST) have been implicated in maladaptive anxiety characteristics of anxiety disorders. However, the underlying circuit and cellular mechanisms have remained elusive. Here we show that mice with

Indexed as

AnimalsAnxietyCentral Amygdaloid NucleusDynorphinsMiceMice, Inbred C57BLMice, KnockoutNeural PathwaysNeuronsReceptor, ErbB-4Septal NucleiSomatostatinDynorphinsErbb4 protein, mouseReceptor, ErbB-4SomatostatinanxietyBNSTcentral amygdaladynorphinErbB4stress

Identifiers

PMID29844022
PMCPMC6001032
OpenAlexW2803613718

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.