ArticleMolecular metabolism2018
Functional analysis reveals differential effects of glutamate and MCH neuropeptide in MCH neurons.
Article in Molecular metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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Who cites it
29 citing papers in PubMed, 46 citations in OpenAlex.
- Modulation of accumbens dopamine by MCH neurons during learning and consummatory behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Glutamatergic Heterogeneity in the Neuropeptide Projections From the Lateral Hypothalamus to the Mouse Olfactory Bulb.The Journal of comparative neurology · 2026Article
- Lack of glutamate neurotransmission in melanin-concentrating hormone neurons alters mouse reproduction and metabolism in a sex-specific manner.Biology of sex differences · 2025Article
- Melanin-Concentrating Hormone Projections to the Nucleus Accumbens Enhance the Reward Value of Food Consumption and Do Not Induce Feeding or REM Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Melanin concentrating hormone projections to the nucleus accumbens enhance the reward value of food consumption and do not induce feeding or REM sleep.bioRxiv : the preprint server for biology · 2024Article
- Regulation of the Mouse Ventral Tegmental Area by Melanin-Concentrating Hormone.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Glutamatergic signaling from melanin-concentrating hormone-producing neurons: A requirement for memory regulation, but not for metabolism control.PNAS nexus · 2024Article
- Exploratory Rearing Is Governed by Hypothalamic Melanin-Concentrating Hormone Neurons According to Locus Ceruleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Distinct lateral hypothalamic CaMKIIα neuronal populations regulate wakefulness and locomotor activity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Hypothalamic MCH Neurons: From Feeding to Cognitive Control.Function (Oxford, England) · 2024Review
- Neuropeptides Modulate Feeding via the Dopamine Reward Pathway.Neurochemical research · 2023Review
- Prostaglandin EProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Fast neurotransmitter identity of MCH neurons: Do contents depend on context?Frontiers in neuroendocrinology · 2023Review
- Orexin and MCH neurons: regulators of sleep and metabolism.Frontiers in neuroscience · 2023Review
- The physiological control of eating: signals, neurons, and networks.Physiological reviews · 2022 · on this mapArticle
- Crosstalk between Melanin Concentrating Hormone and Endocrine Factors: Implications for Obesity.International journal of molecular sciences · 2022Review
- Overexpression of ORX or MCH Protects Neurological Function Against Ischemic Stroke.Neurotoxicity research · 2022Article
- Hypothalamic melanin-concentrating hormone regulates hippocampus-dorsolateral septum activity.Nature neuroscience · 2022Article
- The melanin-concentrating hormone system as a target for the treatment of sleep disorders.Frontiers in neuroscience · 2022Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 3 countries.
Funding
Abstract
objectivesMelanin-concentrating hormone (MCH) neurons in the lateral hypothalamus (LH) regulate food intake and body weight, glucose metabolism and convey the reward value of sucrose. In this report, we set out to establish the respective roles of MCH and conventional neurotransmitters in these neurons.
methodsMCH neurons were profiled using Cre-dependent molecular profiling technologies (vTRAP). MCHCre mice crossed to Vglut2
resultsWe found that nearly all MCH neurons in the LH are glutamatergic and that a loss of glutamatergic signaling from MCH neurons from a glutamate transporter (VGlut2) knockout leads to a reduced weight, hypophagia and hyperkinetic behavior with improved glucose tolerance and a loss of sucrose preference. These effects are indistinguishable from those seen after ablation of MCH neurons. These findings are in contrast to those seen in mice with a knockout of the MCH neuropeptide, which show normal glucose preference and do not have improved glucose tolerance.
conclusionsOverall, these data show that the vast majority of MCH neurons are glutamatergic, and that glutamate and MCH signaling mediate partially overlapping functions by these neurons, presumably by activating partially overlapping postsynaptic populations. The diverse functional effects of MCH neurons are thus mediated by a composite of glutamate and MCH signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.