Evidence map›Paper›PMID 29843844›Full record

ArticleEpidemiology and infection2018

Childhood infectious diseases and risk of multiple myeloma: an analysis of the Italian multicentre case-control study.

E Stagnaro, S Parodi, A Seniori Costantini, P Crosignani, L Miligi, O Nanni, S Piro, V Ramazzotti, S Rodella, R Tumino and 2 more

Open access · bronzeAbstract readMulticenter Study
In one paragraph

Article in Epidemiology and infection, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 10 institutions in 3 countries.

E StagnaroClinical Epidemiology,Ospedale Policlinico San Martino, IRCCS,Genoa,Italy.ORCID 0000-0003-4360-6443
S ParodiEpidemiology and Biostatistics Unit,Istituto Giannina Gaslini,Genoa,Italy.
A Seniori CostantiniUnit of Occupational and Environmental Epidemiology,ISPO,Florence,Italy.
P CrosignaniISDE, Associazione Medici per l'Ambiente,Milan,Italy.
L MiligiUnit of Occupational and Environmental Epidemiology,ISPO,Florence,Italy.
O NanniBiostatistics and Clinical Trials Unit,IRCCS IRST,Meldola (FC),Italy.
S PiroUnit of Occupational and Environmental Epidemiology,ISPO,Florence,Italy.
V RamazzottiEpidemiology Unit,Regina Elena National Cancer Institute,Rome,Italy.
S RodellaHealthcare Development and Evaluation Unit,Agency for Health and Social Care,Bologna,Italy.
R TuminoCancer Registry and Histopathology Unit,'Civile - M.P.Arezzo' Hospital,ASP Ragusa,Italy.
C VindigniPathology Unit,Azienda Ospedaliera Universitaria Senese,Siena,Italy.
P VineisCancer Epidemiology Unit,Imperial College,London,UK.
Istituto per lo Studio e la Prevenzione Oncologica · ITAgenzia Sanitaria e Sociale Regionale · ITAmbiente Italia (Italy) · ITAzienda Ospedaliera Universitaria Senese · ITAzienda Usl 8 Arezzo · ITImperial College London · GBIstituto Giannina Gaslini · ITIstituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori · ITNational Cancer Institute · MYOspedale Policlinico San Martino · IT

Funding

HEMATOLYMPHOPOIETIC MALIGNANCIES IN ITALYR01CA051086 · NCI · UNIVERSITA DI TORINO · PI VINEIS, PAOLO · 1991 to 1993
–
NCI NIH HHS R01 CA051086
6 · The paper itself

Abstract

Common childhood infectious diseases have been associated with a reduced risk of following haematopoietic malignancies, but investigations on multiple myeloma (MM) are scarce. Information about 213 MM cases and 1128 healthy controls were obtained from a multicentre population-based Italian case-control study. The association between chickenpox, measles, mumps, pertussis and rubella and the MM risk was estimated by unconditional logistic regression, adjusting for age, gender and residence area. No association was found between MM risk and any considered infectious disease. The number of infections was slightly inversely associated with the risk of MM, but statistical significance was not reached (OR 0.87, 95% CI 0.55-1.4 for 1-2 diseases vs. none and OR 0.68, 95% CI 0.41-1.1 for 3-5 diseases, respectively, P = 0.131). We did not find a clear evidence that common infections during childhood are associated with the subsequent risk of developing MM.

Indexed as

AdolescentAdultAgedCase-Control StudiesCausalityChickenpoxChildFemaleHumansItalyMaleMeaslesMiddle AgedModels, StatisticalMultiple MyelomaMumpscase-control studychickenpoxchildhood infectionsmeaslesmultiple myelomamumpspertussisrubella

Identifiers

PMID29843844
PMCPMC9507930
OpenAlexW2806787251

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.