Evidence map›Paper›PMID 29843618›Full record

Observational studyBMC cardiovascular disorders2018

Plasma levels of free fatty acid differ in patients with left ventricular preserved, mid-range, and reduced ejection fraction.

Ning Zhu, Wenbing Jiang, Yi Wang, Youyang Wu, Hao Chen, Xuyong Zhao

Open access · goldAbstract readComparative StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC cardiovascular disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ning ZhuDepartment of Cardiology, The Third Clinical College of Wenzhou Medical University, Wenzhou People's Hospital, No. 57 Canghou Street, Wenzhou, 325000, Zhejiang Province, People's Republic of China. zhuningccc@126.com.ORCID 0000-0002-7521-6266
Wenbing JiangDepartment of Cardiology, The Third Clinical College of Wenzhou Medical University, Wenzhou People's Hospital, No. 57 Canghou Street, Wenzhou, 325000, Zhejiang Province, People's Republic of China.
Yi WangDepartment of Cardiology, The Third Clinical College of Wenzhou Medical University, Wenzhou People's Hospital, No. 57 Canghou Street, Wenzhou, 325000, Zhejiang Province, People's Republic of China.
Youyang WuDepartment of Cardiology, The Third Clinical College of Wenzhou Medical University, Wenzhou People's Hospital, No. 57 Canghou Street, Wenzhou, 325000, Zhejiang Province, People's Republic of China.
Hao ChenDepartment of Cardiology, The Third Clinical College of Wenzhou Medical University, Wenzhou People's Hospital, No. 57 Canghou Street, Wenzhou, 325000, Zhejiang Province, People's Republic of China.
Xuyong ZhaoDepartment of Cardiology, The Third Clinical College of Wenzhou Medical University, Wenzhou People's Hospital, No. 57 Canghou Street, Wenzhou, 325000, Zhejiang Province, People's Republic of China.
Wenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFree fatty acids (FFAs) predicted the risk of heart failure (HF) and were elevated in HF with very low left ventricular ejection fraction (LVEF) compared to healthy subjects. The aim of this study was to investigate whether total levels of FFA in plasma differed in patients with HF with preserved (HFpEF), mid-range (HFmrEF), and reduced ejection fraction (HFrEF) and the association with the three categories.

methodsOne hundred thirty-nine patients with HFpEF, HFmrEF and HFrEF were investigated in this study. Plasma FFA levels were measured using commercially available assay kits, and LVEF was calculated by echocardiography with the Simpson biplane method. Dyspnea ranked by New York Heart Association (NYHA) was also identified.

resultsFFA concentrations were higher in HFrEF than in HFmrEF and HFpEF, respectively (689 ± 321.5 μmol/L vs. 537.9 ± 221.6 μmol/L, p = 0.036; 689 ± 321.5 μmol/L vs. 527.5 ± 185.5 μmol/L, p = 0.008). No significant differences in FFA levels were found between HFmrEF and HFpEF (537.9 ± 221.6 μmol/L vs. 527.5 ± 185.5 μmol/L, p = 0.619). In addition, we found a negative correlation between FFA levels and LVEF (regression coefficient: - 0.229, p = 0.004) and a positive correlation between FFAs and NYHA class (regression coefficient: 0.214, p = 0.014) after adjustment for clinical characteristic, medical history and therapies. ROC analysis revealed that FFAs predicted HFrEF across the three categories (AUC: 0.644, p = 0.005) and the optimal cut-off level to predict HFrEF was FFA levels above 575 μmol/L.

conclusionsFFA levels differed across the three categories, which suggests that energy metabolism differs between HFpEF, HFmrEF and HFrEF.

Indexed as

Energy MetabolismStroke VolumeVentricular Function, LeftAgedAged, 80 and overBiomarkersBlood PressureFatty Acids, NonesterifiedFemaleHeart FailureHumansHypertensionMalePilot ProjectsUp-RegulationBiomarkersFatty Acids, NonesterifiedFree fatty acidHeart failureMid-range ejection fractionPreserved ejection fractionReduced ejection fraction

Identifiers

PMID29843618
PMCPMC5975423
OpenAlexW2807167744

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.