ArticleBMC evolutionary biology2018
The effects of repeated whole genome duplication events on the evolution of cytokinin signaling pathway.
Article in BMC evolutionary biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 40 citations in OpenAlex.
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- Genome stabilization in the neotetraploid wasabi (Eutrema japonicum): subgenome dominance and extensive chromosomal rearrangements.BMC plant biology · 2026Article
- Large-Scale Multigenome-Wide Study Predicts the Existence of Transmembrane Phosphotransfer Proteins in Plant Multistep Phosphorelay Signaling Pathway.International journal of molecular sciences · 2025Article
- Identification of the Valine-Glutamine gene family in Chenopodium quinoa Willd and analysis of its expression pattern and subcellular localization under drought stress.BMC genomics · 2025Article
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- Primary multistep phosphorelay activation comprises both cytokinin and abiotic stress responses: insights from comparative analysis of Brassica type-A response regulators.Journal of experimental botany · 2024Article
- Expression and functional divergence of a type-A response regulator paralog pair formed by dispersed duplication during Populus deltoides evolution.Communications biology · 2024Article
- Genomic and Transcriptomic Insights into the Evolution of C4 Photosynthesis in Grasses.Genome biology and evolution · 2024Article
- Large-Scale Identification and Characterization Analysis ofInternational journal of molecular sciences · 2023Article
- Identification and Expression Analysis of Hexokinases Family inPlants (Basel, Switzerland) · 2023Article
- Cytokinin Response Factor 9 Represses Cytokinin Responses in Flower Development.International journal of molecular sciences · 2023Article
- The origin and early evolution of cytokinin signaling.Frontiers in plant science · 2023Review
- Genome-wide identification of the soybean cytokinin oxidase/dehydrogenase gene family and its diverse roles in response to multiple abiotic stress.Frontiers in plant science · 2023Article
- Genome-wide identification of thePeerJ · 2023Article
- Genetic mechanisms underlying increased microalgal thermotolerance, maximal growth rate, and yield on light following adaptive laboratory evolution.BMC biology · 2022Article
- A Comprehensive Identification and Expression Analysis of VQ Motif-Containing Proteins in Sugarcane (International journal of molecular sciences · 2022Article
- msRepDB: a comprehensive repetitive sequence database of over 80 000 species.Nucleic acids research · 2022Article
- Cytokinin Perception in Ancient Plants beyond Angiospermae.International journal of molecular sciences · 2021Article
- Evolution of the Cytokinin Dehydrogenase (CKX) Domain.Journal of molecular evolution · 2021Article
- A sensitive repeat identification framework based on short and long reads.Nucleic acids research · 2021Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is thought that after whole-genome duplications (WGDs), a large fraction of the duplicated gene copies is lost over time while few duplicates are retained. Which factors promote survival or death of a duplicate remains unclear and the underlying mechanisms are poorly understood. According to the model of gene dosage balance, genes encoding interacting proteins are predicted to be preferentially co-retained after WGDs. Among these are genes encoding proteins involved in complexes or in signal transduction.
resultsWe have investigated the way that repeated WGDs during land plant evolution have affected cytokinin signaling to study patterns of gene duplicability and co-retention in this important signal transduction pathway. Through the integration of phylogenetic analyses with comparisons of genome collinearity, we have found that signal input mediated by cytokinin receptors proved to be highly conserved over long evolutionary time-scales, with receptors showing predominantly gene loss after repeated WGDs. However, the downstream elements, e,g. response regulators, were mainly retained after WGDs and thereby formed gene families in most plant lineages.
conclusionsGene dosage balance between the interacting components indicated by co-retention after WGDs seems to play a minor role in the evolution of cytokinin signaling pathway. Overall, core genes of cytokinin signaling show a highly heterogeneous pattern of gene retention after WGD, reflecting complex relationships between the various factors that shape the long-term fate of a duplicated gene.
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