Evidence map›Paper›PMID 29843370›Full record

ArticleMolecules (Basel, Switzerland)2018

Antiproliferative Phenothiazine Hybrids as Novel Apoptosis Inducers against MCF-7 Breast Cancer.

Jun-Xia Zhang, Jiao-Mei Guo, Ting-Ting Zhang, Hong-Jun Lin, Nai-Song Qi, Zhen-Guo Li, Ji-Chun Zhou, Zhen-Zhong Zhang

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jun-Xia ZhangSchool of Pharmaceutical science, Zhengzhou University, Zhengzhou 450001, China. zjx312@163.com.
Jiao-Mei GuoDepartment of Pharmacology, Henan Provincial Institute of Food and Drug Control, Zhengzhou 450008, China. ssjsel745288@163.com.
Ting-Ting ZhangDepartment of Pharmacology, Henan Provincial Institute of Food and Drug Control, Zhengzhou 450008, China. 18637123006@163.com.
Hong-Jun LinDepartment of Pharmacology, Henan Provincial Institute of Food and Drug Control, Zhengzhou 450008, China. 13393723919@163.com.
Nai-Song QiDepartment of Pharmacology, Henan Provincial Institute of Food and Drug Control, Zhengzhou 450008, China. 18538293031@163.com.
Zhen-Guo LiDepartment of Pharmacology, Henan Provincial Institute of Food and Drug Control, Zhengzhou 450008, China. 13298181239@163.com.
Ji-Chun ZhouDepartment of Pharmacology, Henan Provincial Institute of Food and Drug Control, Zhengzhou 450008, China. 18838969948@163.com.
Zhen-Zhong ZhangSchool of Pharmaceutical science, Zhengzhou University, Zhengzhou 450001, China. zhangzhenzhong@zzu.edu.cn.
Henan Provincial Center for Disease Control and Prevention · CNZhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We designed a series of novel phenothiazine-1,2,3-triazole hybrids by the molecular hybridization strategy and evaluated their antiproliferative activity against three cancer cell lines (MDA-MB-231, MDA-MB-468 and MCF-7). For the structure-activity relationships, the importance of 1,2,3-triazole and substituents on phenyl ring was explored. Among these phenothiazine-1,2,3-triazole hybrids, compound

Indexed as

Antineoplastic AgentsApoptosis Regulatory ProteinsBreast NeoplasmsCell CycleCell Line, TumorCell ProliferationCell SurvivalDrug Screening Assays, AntitumorFemaleGene Expression Regulation, NeoplasticHumansMCF-7 CellsMolecular StructurePhenothiazinesStructure-Activity RelationshipAntineoplastic AgentsApoptosis Regulatory ProteinsPhenothiazinesapoptosisDR5MCF-7phenothiazine-1,2,3-triazole

Identifiers

PMID29843370
PMCPMC6100384
OpenAlexW2804643227

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.