ArticleJournal of Parkinson's disease2018
Cardinal Motor Features of Parkinson's Disease Coexist with Peak-Dose Choreic-Type Drug-Induced Dyskinesia.
Article in Journal of Parkinson's disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- MCHR1 in Both Dopaminergic Neurons and Astrocytes in the SNpc Contributes to Acupuncture's Anti-Parkinsonian Effects.Experimental neurobiology · 2026Article
- Enhanced Detection and Segmentation of Sit Phases in Patients with Parkinson's Disease Using a Single SmartWatch and Random Forest Algorithms.Sensors (Basel, Switzerland) · 2025Article
- Enhancing early Parkinson's disease detection through multimodal deep learning and explainable AI: insights from the PPMI database.Scientific reports · 2024Article
- Innovative Detection and Segmentation of Mobility Activities in Patients Living with Parkinson's Disease Using a Single Ankle-Positioned Smartwatch.Sensors (Basel, Switzerland) · 2024Article
- A study on the correlations between acoustic speech variables and bradykinesia in advanced Parkinson's disease.Frontiers in neurology · 2023Article
- Assessment of gait and balance impairment in people with spinocerebellar ataxia using wearable sensors.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Acceptability and Preliminary Results of Technology-Assisted Balance Training in Parkinson's Disease.International journal of environmental research and public health · 2022Article
- Parkinsonian Symptoms, Not Dyskinesia, Negatively Affect Active Life Participation of Dyskinetic Patients with Parkinson's Disease.Tremor and other hyperkinetic movements (New York, N.Y.) · 2020Article
- Can We Predict the Motor Performance of Patients With Parkinson's Disease Based on Their Symptomatology?Frontiers in bioengineering and biotechnology · 2020Article
- The Quebec Parkinson Network: A Researcher-Patient Matching Platform and Multimodal Biorepository.Journal of Parkinson's disease · 2020Article
- Severity of Dyskinesia and D3R Signaling Changes Induced by L-DOPA Treatment of Hemiparkinsonian Rats Are Features Inherent to the Treated Subjects.Biomolecules · 2019Article
- Remnants of Cardinal Symptoms of Parkinson's Disease, Not Dyskinesia, Are Problematic for Dyskinetic Patients Performing Activities of Daily Living.Frontiers in neurology · 2019Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundClinical and anecdotal observations propose that patients with Parkinson's disease (PD) may show drug-induced dyskinesia (DID) concomitantly with cardinal motor features. However, the extent of the concomitant presence of DID and cardinal features remains to be determined.
objectivesThis cross-sectional study measured peak-dose choreic-type DID in a quantitative manner in patients diagnosed with PD, and determined whether symptoms such as tremor, bradykinesia, rigidity, postural instability or freezing of gait (FoG) were still detectable in these patients.
methods89 patients diagnosed with PD were recruited and assessed using a combination of quantitative measures using inertial measurement units to capture DID, tremor, bradykinesia, and FoG. Clinical evaluations were also used to assess rigidity and postural instability. Motor symptoms of PD were assessed 3 times during the testing period, and a series of activities of daily living were repeated twice, in between clinical tests, during which the level of DID was quantified. Peak-dose was identified as the period during which patients had the highest levels of DID. Levels of tremor, rigidity, bradykinesia, postural instability, and FoG were used to determine the percentage of patients showing these motor symptoms simultaneously with DID.
results72.4% of patients tested presented with measurable DID during the experiment. Rest, postural and kinetic tremor (12.7% , 38.1% , and 15.9% respectively), bradykinesia (28.6% ), rigidity (55.6% ), postural instability (71.4% ) and FoG (9.5% ) were detected simultaneously with DID.
conclusionsPD symptomatology remains present in patients showing peak-dose choreic-type DID, illustrating the challenge facing physicians when trying to avoid dyskinesia while attempting to alleviate motor symptoms.
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Registered trials
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