ArticleOsteoarthritis and cartilage2018
A quantitative metric for knee osteoarthritis: reference values of joint space loss.
Article in Osteoarthritis and cartilage, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07066670 (Comparative Effects of Strain Counterstrain and Muscle Energy Technique on Pain, Range of Motion, and Functional Disability in Patients of Knee Osteoarthritis), which is not on this map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparative Effects of Strain Counterstrain and Muscle Energy Technique on Pain, Range of Motion, and Functional Disability in Patients of Knee Osteoarthritis
Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- High-Fidelity Measurement-Based Detection Values and Roles of Three-Dimensional Joint Space Width in Evaluation of Knee Osteoarthritis.Orthopaedic surgery · 2026Article
- Is multi-joint hip and knee osteoarthritis more than the sum of its parts?Osteoarthritis and cartilage open · 2026Article
- High tibial osteotomy achieves unloading of the medial tibiofemoral compartment irrespective of arthritic status or medial collateral ligament release: A biomechanical assessment.Journal of experimental orthopaedics · 2026Article
- Prevalence of osteoarthritis and clinical outcomes in patients with fractures of the tibial plateau - medium- and long-term analysis.BMC musculoskeletal disorders · 2025Observational
- Investigating the relationship between radiographic joint space width loss and deep learning-derived magnetic resonance imaging-based cartilage thickness loss in the medial weight-bearing region of the tibiofemoral joint.Osteoarthritis and cartilage open · 2024Article
- Ten-year trends in values of joint space width and osteophyte area of knee joints: Comparison of the baseline and fourth ROAD study surveys.Osteoarthritis and cartilage open · 2024Article
- Joint line obliquity after lateral closing-wedge high tibial osteotomy does not adversely affect clinical and radiological outcome: a 5-year follow-up study.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Article
- Early Degenerative Changes in a Spontaneous Osteoarthritis Model Assessed by Nanoindentation.Bioengineering (Basel, Switzerland) · 2023Article
- A "best-in-class" systemic biomarker predictor of clinically relevant knee osteoarthritis structural and pain progression.Science advances · 2023Article
- Subchondral tibial bone texture of conventional X-rays predicts total knee arthroplasty.Scientific reports · 2022Article
- Article
- Association between current medication use and progression of radiographic knee osteoarthritis: data from the osteoarthritis initiative.Rheumatology (Oxford, England) · 2021Observational
- Primary Elbow Osteoarthritis: Evaluation and Management.Journal of clinical orthopaedics and trauma · 2021Article
- Synergistic Roles of Macrophages and Neutrophils in Osteoarthritis Progression.Arthritis & rheumatology (Hoboken, N.J.) · 2021Article
- Deep learning risk assessment models for predicting progression of radiographic medial joint space loss over a 48-MONTH follow-up period.Osteoarthritis and cartilage · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesKnee osteoarthritis (OA) onset and progression has been defined with transitions in Kellgren-Lawrence (KL) grade or Osteoarthritis Research Society International (OARSI) Joint Space Narrowing (JSN) grade. We quantitatively describe one-year transitions in KL grade and JSN, using fixed joint space width (fJSW), among knees with or at risk of OA.
methodsRadiographic assessments from the Osteoarthritis Initiative (OAI) were used to identify transitions in KLG and JSN grade between consecutive annual visits. The fJSW was measured in the medial and lateral compartments. The distribution of change in fJSW for KLG and JSN transitions were described, and mean change in fJSW was estimated using mixed models.
resultsKL grade and JSN scores were available for about 20,000 annual transitions from 6047 knees contributed by 3389 participants. Knees that remained stable in KL or OARSI-JSN over 1 year had mean medial fJSW loss between -0.06 and -0.19 mm/year. Transition from KL grade 0 to 1, 0 to 2, and KL 1 to 2 were similar with respect to mean medial fJSW loss (0.18-0.28 mm). Greatest annual changes in medial fJSW corresponded to KL 0 to 3 (1.62 mm), KL 2 to 4 (1.23 mm) and JSN 0 to 2 (1.85 mm).
conclusionsAnchoring quantitatively measured loss of joint space width to transitions in KL grade and JSN provides reference values based on traditional definitions of knee OA onset and progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.