Evidence map›Paper›PMID 29842877›Full record

ArticleExperimental cell research2018

Heterogeneity of adult masseter muscle satellite cells with cardiomyocyte differentiation potential.

Wei Huang, Jialiang Liang, Yuliang Feng, Zhanfeng Jia, Lin Jiang, Wenfeng Cai, Christian Paul, Jianguo G Gu, Peter J Stambrook, Ronald W Millard and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental cell research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Wei HuangDepartment of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Jialiang LiangDepartment of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Yuliang FengDepartment of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Zhanfeng JiaDepartment of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Lin JiangDepartment of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Wenfeng CaiDepartment of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Christian PaulDepartment of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Jianguo G GuDepartment of Anesthesiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Peter J StambrookDepartment of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Ronald W MillardPharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Xiao-Lan ZhuDepartment of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
Ping ZhuDepartment of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China. Electronic address: tanganqier@163.com.
Yigang WangDepartment of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address: yi-gang.wang@uc.edu.
University of Cincinnati Medical Center · USGuangdong Academy of Medical Sciences · CNGuangdong General Hospital · CN

Funding

Autologous Cardiomyocytes from Masseter Muscles to Repair Myocardial Infarction (MI)R01HL136025 · NHLBI · UNIVERSITY OF CINCINNATI · PI DAVIDSON, W SEAN, WANG, YIGANG · 2017 to 2020
$1.8M
Autologous Cardiomyocytes from Masseter Muscles to Repair Myocardial InfarctionR56HL130042 · NHLBI · UNIVERSITY OF CINCINNATI · PI WANG, YIGANG · 2016 to 2016
$473k
NHLBI NIH HHS R01 HL136025NHLBI NIH HHS R56 HL130042
6 · The paper itself

Abstract

Although resident cardiac stem cells have been reported, regeneration of functional cardiomyocytes (CMs) remains a challenge. The present study identifies an alternative progenitor source for CM regeneration without the need for genetic manipulation or invasive heart biopsy procedures. Unlike limb skeletal muscles, masseter muscles (MM) in the mouse head are developed from Nkx2-5 mesodermal progenitors. Adult masseter muscle satellite cells (MMSCs) display heterogeneity in developmental origin and cell phenotypes. The heterogeneous MMSCs that can be characterized by cell sorting based on stem cell antigen-1 (Sca1) show different lineage potential. While cardiogenic potential is preserved in Sca1

Indexed as

Cell DifferentiationAction PotentialsAnimalsAtaxin-1BiomarkersCalciumCell LineageGene ExpressionGenes, ReporterGreen Fluorescent ProteinsHomeobox Protein Nkx-2.5Luminescent ProteinsMasseter MuscleMiceMice, TransgenicMuscle DevelopmentAtaxin-1Atxn1 protein, mouseBiomarkersCalciumGreen Fluorescent ProteinsHomeobox Protein Nkx-2.5Luminescent ProteinsNkx2-5 protein, mousePax7 protein, mousePAX7 Transcription FactorRed Fluorescent ProteinCardiac differentiationCranial masseter muscleRegenerative medicineSatellite cells

Identifiers

PMID29842877
PMCPMC7291879
OpenAlexW2804220648

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.