ArticleThe Journal of cell biology1985
cAMP induces a rapid and reversible modification of the chemotactic receptor in Dictyostelium discoideum.
Article in The Journal of cell biology, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 65 citations in OpenAlex.
- Intracellular adenosine 3',5'-phosphate formation is essential for down-regulation of surface adenosine 3',5'-phosphate receptors in Dictyostelium.The Biochemical journal · 1994Article
- cAMP-induced desensitization of surface cAMP receptors in Dictyostelium: different second messengers mediate receptor phosphorylation, loss of ligand binding, degradation of receptor, and reduction of receptor mRNA levels.Molecular biology of the cell · 1992Article
- Properties of CAR-kinase: the enzyme that phosphorylates the cAMP chemotactic receptor of D. discoideum.Journal of protein chemistry · 1990Article
- Pertussis toxin inhibits cAMP-induced desensitization of adenylate cyclase in Dictyostelium discoideum.Molecular and cellular biochemistry · 1990Article
- GDP stimulates the phosphorylation of a 36-kDa membrane protein in Dictyostelium discoideum.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Evidence for cooperation between cells during sporulation of the yeast Saccharomyces cerevisiae.Molecular and cellular biology · 1988Article
- Quantification of motility and area changes of Dictyostelium discoideum amoebae in response to chemoattractants.Journal of muscle research and cell motility · 1988Article
- Signal transduction in Dictyostelium fgd A mutants with a defective interaction between surface cAMP receptors and a GTP-binding regulatory protein.The Journal of cell biology · 1988Article
- An unusual protein kinase phosphorylates the chemotactic receptor of Dictyostelium discoideum.Proceedings of the National Academy of Sciences of the United States of America · 1988Article
- Molecular basis of transmembrane signal transduction in Dictyostelium discoideum.Microbiological reviews · 1987Review
- A Model Based on Receptor Desensitization for Cyclic AMP Signaling in Dictyostelium Cells.Biophysical journal · 1987Article
- Differential effects of temperature on cAMP-induced excitation, adaptation, and deadaptation of adenylate and guanylate cyclase in Dictyostelium discoideum.The Journal of cell biology · 1987Article
- A molecular mechanism for sensory adaptation based on ligand-induced receptor modification.Proceedings of the National Academy of Sciences of the United States of America · 1986Article
- Probing an adhesion mutant of Dictyostelium discoideum with cDNA clones and monoclonal antibodies indicates a specific defect in the contact site A glycoprotein.The EMBO journal · 1985Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stimulation, within 1 min after cAMP stimulation, of aggregation-competent Dictyostelium discoideum amebae was found to cause a rapid (within 1 min) modification of the cell's surface cAMP receptor. The modified receptor migrated on SDS PAGE as a 47,000-mol-wt protein, as opposed to a 45,000-mol-wt protein labeled on unstimulated cells. The length of time this modified receptor could be detected depended upon the strength of the cAMP stimulus: 3-4 min after treatment with 10(-7) M cAMP, cells no longer possessed the 47,000-mol-wt form of the cAMP receptor. Instead, the 45,000-mol-wt form was present. Stimulation of cells with 10(-5) M cAMP, however, resulted in the persistent (over 15 min) expression of the modified receptor. The time course, concentration dependence, and specificity of stimulus for this cAMP-induced shift in the cAMP receptor were found to parallel the cAMP-stimulated phosphorylation of a 47,000-mol-wt protein. In addition, both phenomena were shown to occur in the absence of endogenous cAMP synthesis. The possibility that the cAMP receptor is phosphorylated in response to cAMP stimulation, and the role of this event in cell desensitization, are discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.