ArticlePloS one2018
Creatine kinase is associated with reduced inflammation in a general population: The Tromsø study.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Multi-ancestry genome-wide association study of serum creatine kinase implicates myopathy genes and muscle pathways.EBioMedicine · 2026Pooled it
- Polygenic Risk Scores Predicting Estimated GFR Validated With Iohexol Clearance.Kidney international reports · 2026Article
- Practical Recommendations on Laboratory Monitoring in Patients with Atopic Dermatitis on Oral JAK Inhibitors.Dermatology and therapy · 2024Article
- Immunology of Physical Exercise: IsInternational journal of molecular sciences · 2024Review
- Diagnosis of T-cell-mediated kidney rejection by biopsy-based proteomic biomarkers and machine learning.Frontiers in immunology · 2023Article
- Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study.PloS one · 2023Article
- Utility of routine laboratory tests in the assessment of chronic venous disease progression in female patients.Experimental and therapeutic medicine · 2022Article
- Evaluation of dietary mycotoxin control strategies on nursery pig growth performance and blood measures.Translational animal science · 2022Article
- Association of High-Density Lipoprotein Cholesterol With GFR Decline in a General Nondiabetic Population.Kidney international reports · 2021Article
- Anti-Inflammatory Potentials of the n-Hexane Fraction ofJournal of inflammation research · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCreatine kinase (CK) has been associated with reduced inflammation in obesity while inflammation is associated with obesity-related cardiovascular diseases. We investigated the relationship between CK and high sensitive C-reactive protein (hs-CRP) in a general population.
methodsCK and hs-CRP were measured in the population-based Tromsø study that included entire birth cohorts and random samples of citizens between 30-87 years of age. The analyses were performed sex-stratified in 5969 men and 6827 women.
resultsCK correlated negatively with hs-CRP in men (r = -0.08, P <0.001) and women (r = -0.06, P <0.001). In univariable regression analyses, CK associated negatively with hs-CRP in men (ß = -0.14, 95% CI -0.19 to -0.10, P <0.001) and women (ß = -0.13, 95% CI -0.18 to -0.08, P <0.001). Mean CK declined from the 2. to the 4. quartiles of hs-CRP in both genders (P <0.001 for trends). There were positive correlations between CK and body mass index (BMI) in men (r = 0.10, P <0.001) and women (r = 0.07, P <0.001). Multiple regression analyses showed a 0.13 unit decrease in hs-CRP (mg/dl) per unit CK increase in men (95% CI -0.35 to -0.20) and 0.29 mg/dl in women (95% CI -0.36 to -0.21) when adjusted for age, BMI, lipids, s-glucose, s-creatinine, transaminases and coronary heart disease.
conclusionCK were inversely and independently associated with hs-CRP in a general population. These data provide evidence that CK might have anti-inflammatory properties, but the mechanism and clinical implications are unclarified.
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