ArticlePLoS computational biology2018
Quantitative theory of deep brain stimulation of the subthalamic nucleus for the suppression of pathological rhythms in Parkinson's disease.
Article in PLoS computational biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Article
- Subthalamic Nucleus Activity during Cognitive Load and Gait Dysfunction in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2023Article
- Microscale multicircuit brain stimulation: Achieving real-time brain state control for novel applications.Current research in neurobiology · 2023Review
- Therapeutic Devices for Motor Symptoms in Parkinson's Disease: Current Progress and a Systematic Review of Recent Randomized Controlled Trials.Frontiers in aging neuroscience · 2022Review
- Subthalamic nucleus activity dynamics and limb movement prediction in Parkinson's disease.Brain : a journal of neurology · 2020Article
- Advances in neurochemical measurements: A review of biomarkers and devices for the development of closed-loop deep brain stimulation systems.Reviews in analytical chemistry · 2020Article
- Deep brain stimulation has state-dependent effects on motor connectivity in Parkinson's disease.Brain : a journal of neurology · 2019Article
- Application of a Novel Measurement Setup for Characterization of Graphene Microelectrodes and a Comparative Study of Variables Influencing Charge Injection Limits of Implantable Microelectrodes.Sensors (Basel, Switzerland) · 2019Article
- A Measurement Setup and Automated Calculation Method to Determine the Charge Injection Capacity of Implantable Microelectrodes.Sensors (Basel, Switzerland) · 2018Article
- Suppression of Parkinsonian Beta Oscillations by Deep Brain Stimulation: Determination of Effective Protocols.Frontiers in computational neuroscience · 2018Article
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2 authors.
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Abstract
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is modeled to explore the mechanisms of this effective, but poorly understood, treatment for motor symptoms of drug-refractory Parkinson's disease and dystonia. First, a neural field model of the corticothalamic-basal ganglia (CTBG) system is developed that reproduces key clinical features of Parkinson's disease, including its characteristic 4-8 Hz and 13-30 Hz electrophysiological signatures. Deep brain stimulation of the STN is then modeled and shown to suppress the pathological 13-30 Hz (beta) activity for physiologically realistic and optimized stimulus parameters. This supports the idea that suppression of abnormally coherent activity in the CTBG system is a major factor in DBS therapy for Parkinson's disease, by permitting normal dynamics to resume. At high stimulus intensities, nonlinear effects in the target population mediate wave-wave interactions between resonant beta activity and the stimulus pulse train, leading to complex spectral structure that shows remarkable similarity to that seen in steady-state evoked potential experiments.
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