Evidence map›Paper›PMID 29812968›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2018

Human mesenchymal stromal cell-derived extracellular vesicles attenuate aortic aneurysm formation and macrophage activation via microRNA-147.

Michael Spinosa, Guanyi Lu, Gang Su, Sai Vineela Bontha, Ricardo Gehrau, Morgan D Salmon, Joseph R Smith, Mark L Weiss, Valeria R Mas, Gilbert R Upchurch and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.

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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Michael SpinosaDepartment of Surgery, University of Virginia, Charlottesville, Virginia, USA.
Guanyi LuDepartment of Surgery, University of Virginia, Charlottesville, Virginia, USA.
Gang SuDepartment of Surgery, University of Virginia, Charlottesville, Virginia, USA.
Sai Vineela BonthaDepartment of Surgery, University of Virginia, Charlottesville, Virginia, USA.
Ricardo GehrauDepartment of Surgery, University of Virginia, Charlottesville, Virginia, USA.
Morgan D SalmonDepartment of Surgery, University of Virginia, Charlottesville, Virginia, USA.
Joseph R SmithDepartment of Anatomy and Physiology, Kansas State University, Manhattan, Kansas, USA.
Mark L WeissDepartment of Anatomy and Physiology, Kansas State University, Manhattan, Kansas, USA.
Valeria R MasDepartment of Surgery, University of Virginia, Charlottesville, Virginia, USA.
Gilbert R UpchurchDepartment of Surgery, University of Virginia, Charlottesville, Virginia, USA.
Ashish K SharmaDepartment of Surgery, University of Virginia, Charlottesville, Virginia, USA.
University of Virginia · USKansas State University · US

Funding

Gender Differences in Experimental Aortic AneurysmsR01HL081629 · NHLBI · UNIVERSITY OF VIRGINIA · PI UPCHURCH, GILBERT RIVERS · 2007 to 2017
$4.1M
NHLBI NIH HHS R01 HL081629
6 · The paper itself

Abstract

The formation of an abdominal aortic aneurysm (AAA) is characterized by inflammation, macrophage infiltration, and vascular remodeling. In this study, we tested the hypothesis that mesenchymal stromal cell (MSC)-derived extracellular vesicles (EVs) immunomodulate aortic inflammation, to mitigate AAA formation via modulation of microRNA-147. An elastase-treatment model of AAA was used in male C57BL/6 wild-type (WT) mice. Administration of EVs in elastase-treated WT mice caused a significant attenuation of aortic diameter and mitigated proinflammatory cytokines, inflammatory cell infiltration, an increase in smooth muscle cell α-actin expression, and a decrease in elastic fiber disruption, compared with untreated mice. A 10-fold up-regulation of microRNA (miR)-147, a key mediator of macrophage inflammatory responses, was observed in murine aortic tissue in elastase-treated mice compared with controls on d 14. EVs derived from MSCs transfected with miR-147 mimic, but not with miR-147 inhibitor, attenuated aortic diameter, inflammation, and leukocyte infiltration in elastase-treated mice. In vitro studies of human aortic tissue explants and murine-derived CD11b

Indexed as

exosomeshigh mobility group box 1IL-17inflammationstem cells

Identifiers

PMID29812968
PMCPMC6181641
OpenAlexW2805782810

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.