Evidence map›Paper›PMID 29809298›Full record

Observational studyTransplant infectious disease : an official journal of the Transplantation Society2018

Community-acquired respiratory virus lower respiratory tract disease in allogeneic stem cell transplantation recipient: Risk factors and mortality from pulmonary virus-bacterial mixed infections.

José Luis Piñana, María Dolores Gómez, Ariadna Pérez, Silvia Madrid, Aitana Balaguer-Roselló, Estela Giménez, Juan Montoro, Eva María González, Víctor Vinuesa, Paula Moles and 7 more

Abstract readComparative StudyObservational Study
In one paragraph

Observational study in Transplant infectious disease : an official journal of the Transplantation Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Microbiological risk factors, ICU survival, and 1-year survival in hematological patients with pneumonia requiring invasive mechanical ventilation.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

José Luis PiñanaHematology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain.ORCID http://orcid.org/0000-0001-8533-2562
María Dolores GómezMicrobiology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
Ariadna PérezHematology Department, Institute for Research INCLIVA, Hospital Clínico Universitario, Valencia, Spain.
Silvia MadridMicrobiology Department, Institute for Research INCLIVA, Hospital Clínico Universitario, Valencia, Spain.
Aitana Balaguer-RosellóHematology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
Estela GiménezMicrobiology Department, Institute for Research INCLIVA, Hospital Clínico Universitario, Valencia, Spain.
Juan MontoroHematology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
Eva María GonzálezMicrobiology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
Víctor VinuesaMicrobiology Department, Institute for Research INCLIVA, Hospital Clínico Universitario, Valencia, Spain.
Paula MolesDermatology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
Juan Carlos Hernández-BoludaHematology Department, Institute for Research INCLIVA, Hospital Clínico Universitario, Valencia, Spain.
Miguel SalavertDepartment of Infectious Diseases, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
Marisa CalabuigHematology Department, Institute for Research INCLIVA, Hospital Clínico Universitario, Valencia, Spain.
Guillermo SanzHematology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
Carlos SolanoHematology Department, Institute for Research INCLIVA, Hospital Clínico Universitario, Valencia, Spain.
Jaime SanzHematology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
David NavarroMicrobiology Department, Institute for Research INCLIVA, Hospital Clínico Universitario, Valencia, Spain.ORCID http://orcid.org/0000-0003-3010-4110

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Risk factors (RFs) and mortality data of community-acquired respiratory virus (CARVs) lower respiratory tract disease (LRTD) with concurrent pulmonary co-infections in the setting of allogeneic hematopoietic stem cell transplantation (allo-HSCT) is scarce. From January 2011 to December 2017, we retrospectively compared the outcome of allo-HSCT recipients diagnosed of CARVs LRTD mono-infection (n = 52, group 1), to those with viral, bacterial, or fungal pulmonary CARVs LRTD co-infections (n = 15, group 2; n = 20, group 3, and n = 11, group 4, respectively), and with those having bacterial pneumonia mono-infection (n = 19, group 5). Overall survival (OS) at day 60 after bronchoalveolar lavage (BAL) was significantly higher in group 1, 2, and 4 compared to group 3 (77%, 67%, and 73% vs 35%, respectively, P = .012). Recipients of group 5 showed a trend to better OS compared to those of group 3 (62% vs 35%, P = .1). Multivariate analyses showed bacterial co-infection as a RF for mortality (hazard ratio[HR] 2.65, 95% C.I. 1.2-6.9, P = .017). We identified other 3 RFs for mortality: lymphocyte count <0.5 × 10

Indexed as

AdultAgedAntiviral AgentsBacteriaBronchoalveolar LavageBronchoalveolar Lavage FluidCoinfectionCommunity-Acquired InfectionsFemaleFungiHematopoietic Stem Cell TransplantationHumansLungMaleMiddle AgedRespiratory Tract InfectionsAntiviral Agentsallogeneic hematopoietic stem cell transplantationCMV DNAemiacommunity acquired respiratory virusimmunodeficiency score indexrespiratory virus co-infectionsvirus-bacterial mixed infections

Identifiers

PMID29809298
PMCPMC7169706

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.