Evidence map›Paper›PMID 29809174›Full record

ArticleScientific data2018

Micro-computed tomography reconstructions of tibiae of stem cell transplanted osteogenesis imperfecta mice.

Anna M Ranzoni, Michelangelo Corcelli, Timothy R Arnett, Pascale V Guillot

Abstract readDataset
In one paragraph

Article in Scientific data, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Anna M RanzoniInstitute for Women's Health, University College London, WC1E 6AU London, UK.
Michelangelo CorcelliInstitute for Women's Health, University College London, WC1E 6AU London, UK.
Timothy R ArnettDepartment of Cell & Developmental Biology, University College London, WC1E 6BT London, UK.
Pascale V GuillotInstitute for Women's Health, University College London, WC1E 6AU London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Micro-computed tomography (micro-CT) is commonly used to assess bone quality and to evaluate the outcome of experimental therapies in animal models of bone diseases. Generating large datasets is however challenging and data are rarely made publicly available through shared repositories. Here we describe a dataset of micro-CT reconstructed scans of the proximal part of 21 tibiae from wild-type mice, osteogenesis imperfecta mice (homozygous oim/oim) and oim/oim mice transplanted with human amniotic fluid stem cells. The dataset contains, for each sample, 991 8-bit Bitmap reconstructed images and a 3D reconstruction of the bone in the PLY format, available at the online repository Figshare. In line with the increasing effort to make scientific datasets open-access, our data can be downloaded and used by other researchers to compare their observations with ours and to directly test scientific questions on osteogenesis imperfecta bones without the need to generate complete datasets.

Indexed as

Osteogenesis ImperfectaStem Cell TransplantationAnimalsHumansMiceStem CellsTibiaX-Ray Microtomography

Identifiers

PMID29809174
PMCPMC5972671

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.