Evidence map›Paper›PMID 29809147›Full record

ArticleeLife2018

A twist defect mechanism for ATP-dependent translocation of nucleosomal DNA.

Jessica Winger, Ilana M Nodelman, Robert F Levendosky, Gregory D Bowman

Abstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Article
  2. Article
  3. Rotational settings quantize nucleosome movement by chromatin regulators.bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Sequence Dependence in Nucleosome Dynamics.The journal of physical chemistry. B · 2024
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jessica WingerT.C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, United States.ORCID http://orcid.org/0000-0003-2109-3560
Ilana M NodelmanT.C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, United States.
Robert F LevendoskyT.C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, United States.ORCID http://orcid.org/0000-0002-5101-0810
Gregory D BowmanT.C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, United States.ORCID http://orcid.org/0000-0001-8025-4315

Funding

CELLULAR AND MOLECULAR BIOLOGYT32GM007231 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI VAN DOREN, MARK B · 1985 to 2020
$18.4M
Structural and Functional Characterization of the Chd1 Chromatin RemodelerR01GM084192 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI BOWMAN, GREGORY DEAN · 2008 to 2024
$6.3M
NIGMS NIH HHS R01 GM084192NIGMS NIH HHS T32 GM007231NIH HHS R01-GM084192
6 · The paper itself

Abstract

As superfamily 2 (SF2)-type translocases, chromatin remodelers are expected to use an inchworm-type mechanism to walk along DNA. Yet how they move DNA around the histone core has not been clear. Here we show that a remodeler ATPase motor can shift large segments of DNA by changing the twist and length of nucleosomal DNA at superhelix location 2 (SHL2). Using canonical and variant 601 nucleosomes, we find that the

Indexed as

AcyltransferasesAdenosine TriphosphatasesAdenosine TriphosphateDNA-Binding ProteinsDNA, FungalDNA, SuperhelicalNucleic Acid ConformationNucleosomesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsAcyltransferasesAdenosine TriphosphatasesAdenosine TriphosphateCHD1 protein, S cerevisiaeDNA-Binding ProteinsDNA, FungalDNA, SuperhelicalISW1 protein, S cerevisiaeNucleosomesSaccharomyces cerevisiae ProteinsSwf1 protein, S cerevisiaebiochemistrychemical biologychromatin remodelingchromosomesDNA translocationgene expressionnucleosomeS. cerevisiaeSnf2 ATPasesuperfamily 2 ATPasetwist defectxenopus

Identifiers

PMID29809147
PMCPMC6031429

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.