ArticleeLife2018
A cerebellar substrate for cognition evolved multiple times independently in mammals.
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 64 citations in OpenAlex.
- How does the cerebellum contribute to cognitive functions?PLoS biology · 2026Review
- The genetic architecture of human cerebellar morphology supports a key role for the cerebellum in human evolution and psychopathology.Communications biology · 2026Article
- Human-specific features of the cerebellum and ZP2-regulated synapse development.bioRxiv : the preprint server for biology · 2025Article
- Lateralized cerebellar connectivity differentiates auditory pathways in echolocating and non-echolocating whales.PloS one · 2025Article
- Article
- Understanding the role of AMPA receptors in autism: insights from circuit and synapse dysfunction.Frontiers in psychiatry · 2024Review
- A Comparative Perspective on the Cerebello-Cerebral System and Its Link to Cognition.Cerebellum (London, England) · 2023Review
- Phylogenetic comparative analysis of the cerebello-cerebral system in 34 species highlights primate-general expansion of cerebellar crura I-II.Communications biology · 2023Article
- Article
- Epigenetic ageing of the prefrontal cortex and cerebellum in humans and chimpanzees.Epigenetics · 2022Article
- Human Cerebellar Development and Transcriptomics: Implications for Neurodevelopmental Disorders.Annual review of neuroscience · 2022Review
- The evolution of brain neuron numbers in amniotes.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The evolution of quantitative sensitivity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- A quantitative analysis of cerebellar anatomy in birds.Brain structure & function · 2021Article
- Comparative analysis reveals distinctive epigenetic features of the human cerebellum.PLoS genetics · 2021Article
- The evolution of mammalian brain size.Science advances · 2021Article
- Abnormal Cerebellar Development in Autism Spectrum Disorders.Developmental neuroscience · 2021Review
- Why big brains? A comparison of models for both primate and carnivore brain size evolution.PloS one · 2021Article
- Aging: What We Can Learn From Elephants.Frontiers in aging · 2021Review
- Evidence for Hierarchical Cognitive Control in the Human Cerebellum.Current biology : CB · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Given that complex behavior evolved multiple times independently in different lineages, a crucial question is whether these independent evolutionary events coincided with modifications to common neural systems. To test this question in mammals, we investigate the lateral cerebellum, a neurobiological system that is novel to mammals, and is associated with higher cognitive functions. We map the evolutionary diversification of the mammalian cerebellum and find that relative volumetric changes of the lateral cerebellar hemispheres (independent of cerebellar size) are correlated with measures of domain-general cognition in primates, and are characterized by a combination of parallel and convergent shifts towards similar levels of expansion in distantly related mammalian lineages. Results suggest that multiple independent evolutionary occurrences of increased behavioral complexity in mammals may at least partly be explained by selection on a common neural system, the cerebellum, which may have been subject to multiple independent neurodevelopmental remodeling events during mammalian evolution.
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