ArticleeLife2018
Targeted cortical reorganization using optogenetics in non-human primates.
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- On the impact of tactile processing on motor cortex: how touch shapes motor behaviour.Brain structure & function · 2026Review
- Multimodal Layer-Crossing Interrogation of Brain Circuits Enabled by Microfluidic Axialtrodes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A large-scale optogenetic neurophysiology platform for improving accessibility in non-human primate behavioral experiments.Nature communications · 2026Article
- Article
- Brain-Computer Interfaces for Vision Recovery in Precortical Vision Loss.Eye and brain · 2026Review
- Flexible modeling of large-scale neural network stimulation: Electrical and optical extensions to The Virtual Electrode Recording Tool for EXtracellular Potentials (VERTEX).Journal of neuroscience methods · 2025Article
- A large-scale optogenetic neurophysiology platform for improving accessibility in non-human primate behavioral experiments.bioRxiv : the preprint server for biology · 2025Article
- Inferring Neural Communication Dynamics from Field Potentials Using Graph Diffusion Autoregression.bioRxiv : the preprint server for biology · 2025Article
- Flexible modeling of large-scale neural network stimulation: electrical and optical extensions to The Virtual Electrode Recording Tool for EXtracellular Potentials (VERTEX).bioRxiv : the preprint server for biology · 2025Article
- NSF DARE-Transforming modeling in neurorehabilitation: Four threads for catalyzing progress.Journal of neuroengineering and rehabilitation · 2024Review
- A Neural Implant Design Toolbox for Nonhuman Primates.Journal of visualized experiments : JoVE · 2024Article
- From imaging to precision: low cost and accurate determination of stereotactic coordinates for brain surgeryFrontiers in neuroscience · 2024Article
- Causally informed activity flow models provide mechanistic insight into network-generated cognitive activations.NeuroImage · 2023Article
- Review
- Pathological changes of brain oscillations following ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Review
- Improving the Efficacy and Accessibility of Intracranial Viral Vector Delivery in Non-Human Primates.Pharmaceutics · 2022Article
- Demonstration of an Optimized Large-scale Optogenetic Cortical Interface for Non-human Primates.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2022Article
- Network structure mediates functional reorganization induced by optogenetic stimulation of non-human primate sensorimotor cortex.iScience · 2022Article
- A versatile toolbox for studying cortical physiology in primates.Cell reports methods · 2022Article
- Dissecting the Prefrontal Network With Pathway-Selective Manipulation in the Macaque Brain-A Review.Frontiers in neuroscience · 2022Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain stimulation modulates the excitability of neural circuits and drives neuroplasticity. While the local effects of stimulation have been an active area of investigation, the effects on large-scale networks remain largely unexplored. We studied stimulation-induced changes in network dynamics in two macaques. A large-scale optogenetic interface enabled simultaneous stimulation of excitatory neurons and electrocorticographic recording across primary somatosensory (S1) and motor (M1) cortex (Yazdan-Shahmorad et al., 2016). We tracked two measures of network connectivity, the network response to focal stimulation and the baseline coherence between pairs of electrodes; these were strongly correlated before stimulation. Within minutes, stimulation in S1 or M1 significantly strengthened the gross functional connectivity between these areas. At a finer scale, stimulation led to heterogeneous connectivity changes across the network. These changes reflected the correlations introduced by stimulation-evoked activity, consistent with Hebbian plasticity models. This work extends Hebbian plasticity models to large-scale circuits, with significant implications for stimulation-based neurorehabilitation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.