ArticleBehavioral neuroscience2018
Early adolescent adversity inflates threat estimation in females and promotes alcohol use initiation in both sexes.
Article in Behavioral neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Alcohol Use, Cannabis Use, and Discrimination by Sexual Orientation and Gender Identity Within theLGBT health · 2026Article
- Paraventricular thalamic inputs to the ventral pallidum shape reward seeking during threat and fear responding in extinction.Behavioral neuroscience · 2025Article
- Ethograms reveal a fear conditioned visual cue to organize diverse behaviors.bioRxiv : the preprint server for biology · 2024Article
- Article
- Optogenetic inhibition of the caudal substantia nigra inflates behavioral responding to uncertain threat and safety.Behavioral neuroscience · 2023Article
- Optogenetic inhibition of the caudal substantia nigra inflates behavioral responding to uncertain threat and safety.bioRxiv : the preprint server for biology · 2023Article
- Timing of behavioral responding to long-duration Pavlovian fear conditioned cues.bioRxiv : the preprint server for biology · 2023Article
- Stress and sex-dependent effects on conditioned inhibition of fear.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Threat and Bidirectional Valence Signaling in the Nucleus Accumbens Core.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Retrorubral field is a hub for diverse threat and aversive outcome signals.Current biology : CB · 2021Article
- Neural substrates of appetitive and aversive prediction error.Neuroscience and biobehavioral reviews · 2021Review
- Foot shock facilitates reward seeking in an experience-dependent manner.Behavioural brain research · 2021Article
- Ventral pallidum neurons dynamically signal relative threat.Communications biology · 2021Article
- Early adolescent adversity alters periaqueductal gray/dorsal raphe threat responding in adult female rats.Scientific reports · 2020Article
- The neurobiological basis of sex differences in learned fear and its inhibition.The European journal of neuroscience · 2020Review
- The Nucleus Accumbens Core is Necessary to Scale Fear to Degree of Threat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The ventrolateral periaqueductal grey updates fear via positive prediction error.The European journal of neuroscience · 2020Article
- Article
- Individual differences in voluntary alcohol consumption are associated with conditioned fear in the fear incubation model.Behavioural brain research · 2019Article
- Ventrolateral periaqueductal gray neurons prioritize threat probability over fear output.eLife · 2019Article
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Authors and funding
4 authors.
Funding
Abstract
Childhood adversity is associated with exaggerated threat processing and earlier alcohol use initiation. Conclusive links remain elusive, as childhood adversity typically co-occurs with detrimental socioeconomic factors, and its impact is likely moderated by biological sex. To unravel the complex relationships among childhood adversity, sex, threat estimation, and alcohol use initiation, we exposed female and male Long-Evans rats to early adolescent adversity (EAA). In adulthood, >50 days following the last adverse experience, threat estimation was assessed using a novel fear discrimination procedure in which cues predict a unique probability of footshock: danger (p = 1.00), uncertainty (p = .25), and safety (p = .00). Alcohol use initiation was assessed using voluntary access to 20% ethanol, >90 days following the last adverse experience. During development, EAA slowed body weight gain in both females and males. In adulthood, EAA selectively inflated female threat estimation, exaggerating fear to uncertainty and safety, but promoted alcohol use initiation across sexes. Meaningful relationships between threat estimation and alcohol use initiation were not observed, underscoring the independent effects of EAA. Results isolate the contribution of EAA to adult threat estimation, alcohol use initiation, and reveal moderation by biological sex. (PsycINFO Database Record
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