Evidence map›Paper›PMID 29808945›Full record

ReviewJournal of cellular and molecular medicine2018

Endothelial microvesicles in hypoxic hypoxia diseases.

Fan Deng, Shuang Wang, Riping Xu, Wenqian Yu, Xianyu Wang, Liangqing Zhang

Open access · goldAbstract readReview
In one paragraph

Review in Journal of cellular and molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Microvesicles in plasma reflect coronary flow reserve in patients with cardiovascular disease.American journal of physiology. Heart and circulatory physiology · 2021
    Article
  8. Clinical Characteristics and Outcomes of Patients with Severe COVID-19 and Chronic Obstructive Pulmonary Disease (COPD).Medical science monitor : international medical journal of experimental and clinical research · 2020
    Article
  9. Review
  10. Article
  11. Article
  12. Endothelial microvesicles in hypoxic hypoxia diseases.Journal of cellular and molecular medicine · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Fan DengDepartment of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Shuang WangDongfeng General Hospital, Hubei University of Medicine, Shiyan, China.
Riping XuDepartment of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Wenqian YuDepartment of Anesthesiology, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
Xianyu WangDepartment of Anesthesiology, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
Liangqing ZhangDepartment of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Affiliated Hospital of Guangdong Medical College Hospital · CNTaihe Hospital · CNDongfeng General Hospital · CNGuangdong Medical College · CN

Funding

National Natural Science of China 81270196National Natural Science of China 81470405
6 · The paper itself

Abstract

Hypoxic hypoxia, including abnormally low partial pressure of inhaled oxygen, external respiratory dysfunction-induced respiratory hypoxia and venous blood flow into the arterial blood, is characterized by decreased arterial oxygen partial pressure, resulting in tissue oxygen deficiency. The specific characteristics include reduced arterial oxygen partial pressure and oxygen content. Hypoxic hypoxia diseases (HHDs) have attracted increased attention due to their high morbidity and mortality and mounting evidence showing that hypoxia-induced oxidative stress, coagulation, inflammation and angiogenesis play extremely important roles in the physiological and pathological processes of HHDs-related vascular endothelial injury. Interestingly, endothelial microvesicles (EMVs), which can be induced by hypoxia, hypoxia-induced oxidative stress, coagulation and inflammation in HHDs, have emerged as key mediators of intercellular communication and cellular functions. EMVs shed from activated or apoptotic endothelial cells (ECs) reflect the degree of ECs damage, and elevated EMVs levels are present in several HHDs, including obstructive sleep apnoea syndrome and chronic obstructive pulmonary disease. Furthermore, EMVs have procoagulant, proinflammatory and angiogenic functions that affect the pathological processes of HHDs. This review summarizes the emerging roles of EMVs in the diagnosis, staging, treatment and clinical prognosis of HHDs.

Indexed as

biomarkersendothelial microvesicleshypoxiaischaemic

Identifiers

PMID29808945
PMCPMC6050493
OpenAlexW2805841809

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.