ArticleAntioxidants & redox signaling2019
Targeting of PP2Cδ By a Small Molecule C23 Inhibits High Glucose-Induced Breast Cancer Progression
Open access · greenAbstract read
In one paragraph
Article in Antioxidants & redox signaling, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 37% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- The role of PPM1D in cancer and advances in studies of its inhibitors.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2020Pooled it
- Antiproliferative effect of ketogenic diet on hormone independent mammary gland carcinoma via harnessing glucose metabolism: In-vitro and In-vivo investigations.Journal, genetic engineering & biotechnology · 2025Article
- Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state.Nature communications · 2022Article
- A Novel Metabolic Reprogramming Strategy for the Treatment of Diabetes-Associated Breast Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- High glucose: an emerging association between diabetes mellitus and cancer progression.Journal of molecular medicine (Berlin, Germany) · 2021Review
- Ginsenoside Rh1 Induces MCF-7 Cell Apoptosis and Autophagic Cell Death through ROS-Mediated Akt Signaling.Cancers · 2021Article
- Comp34 displays potent preclinical antitumor efficacy in triple-negative breast cancer via inhibition of NUDT3-AS4, a novel oncogenic long noncoding RNA.Cell death & disease · 2020Article
- Consideration of Ketogenic Metabolic Therapy as a Complementary or Alternative Approach for Managing Breast Cancer.Frontiers in nutrition · 2020Review
- PP2Cδ inhibits p300-mediated p53 acetylation via ATM/BRCA1 pathway to impede DNA damage response in breast cancer.Science advances · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 9 institutions in 3 countries.
Ke Wu1 Division of Cancer Research and Training, Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, California.
Xiaoting Yu3 Department of Pathology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
Zhimin Huang4 Key Laboratory of Cell Differentiation and Apoptosis of The Chinese Ministry of Education, Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Chemical Biology Division of Shanghai Universities E-Institutes, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Donghui Zhu5 Department of Biomedical Engineering, University of North Texas, Denton, Texas.
Xianghua Yi3 Department of Pathology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
Ying-Li Wu4 Key Laboratory of Cell Differentiation and Apoptosis of The Chinese Ministry of Education, Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Chemical Biology Division of Shanghai Universities E-Institutes, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Qiongyu Hao1 Division of Cancer Research and Training, Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, California.
Kevin T Kemp1 Division of Cancer Research and Training, Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, California.
Yahya Elshimali1 Division of Cancer Research and Training, Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, California.
Roshni Iyer6 Department of Biomedical Engineering, University of Texas at Arlington, Arlington, Texas.
Kytai Truong Nguyen6 Department of Biomedical Engineering, University of Texas at Arlington, Arlington, Texas.
Shilong Zheng7 RCMI Cancer Research Center, Xavier University of Louisiana, New Orleans, Louisiana.
Guanglin Chen9 Department of Chemistry, California State University, Fresno, Fresno, California.
Qiao-Hong Chen9 Department of Chemistry, California State University, Fresno, Fresno, California.
Guangdi Wang7 RCMI Cancer Research Center, Xavier University of Louisiana, New Orleans, Louisiana.
Jaydutt V Vadgama1 Division of Cancer Research and Training, Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, California.
Yong Wu1 Division of Cancer Research and Training, Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, California.
University of California, Los Angeles · USXavier University of Louisiana · USCharles R. Drew University of Medicine and Science · USThe University of Texas at Arlington · USTongji University · CNCalifornia State University, Fresno · USMinistry of Education · THUniversity of North Texas · USWuhan University · CN
Funding
Workshop for Junior Biostatisticians in Health ResearchU54MD007598 · NIMHD · CHARLES R. DREW UNIVERSITY OF MED & SCI · PI Ali Andalibi, Jose A Torres-Ruiz · 2012 to 2026
$60.0MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MSupporting African American Churches to Promote Cancer ScreeningU54CA143931 · NCI · CHARLES R. DREW UNIVERSITY OF MED & SCI · PI VADGAMA, JAYDUTT V. · 2009 to 2022
$19.7MXavier's RCMI Cancer Research ProgramG12MD007595 · NIMHD · XAVIER UNIVERSITY OF LOUISIANA · PI D'AMOUR, GENE, WANG, GUANGDI · 2012 to 2018
$15.7MTraining and Mentoring ProgramsU54CA143930 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PIETRAS, RICHARD JOSEPH · 2009 to 2020
$7.5MA novel metabolic reprograming strategy for the treatment of diabetes-associated breast cancerSC1GM135050 · NIGMS · CHARLES R. DREW UNIVERSITY OF MED & SCI · PI WU, YONG · 2020 to 2023
$1.4MMechanisms behind hyperglycemia-associated breast cancer risk and progressionSC1CA200517 · NCI · CHARLES R. DREW UNIVERSITY OF MED & SCI · PI WU, YONG · 2015 to 2018
$1.4MDrew/UCLA Cancer Partnership ProgramU56CA101599 · NCI · CHARLES R. DREW UNIVERSITY OF MED &SCI · PI VADGAMA, JAYDUTT V. · 2003 to 2009
$1.3MNCATS NIH HHS UL1 TR000124NCI NIH HHS SC1 CA200517NCI NIH HHS U54 CA143930NCI NIH HHS U54 CA143931NCI NIH HHS U56 CA101599NIGMS NIH HHS SC1 GM135050NIMHD NIH HHS G12 MD007595NIMHD NIH HHS U54 MD007598
Abstract
PubMed holds no abstract for this paper.
Indexed as
AcetylationAnimalsAntineoplastic AgentsBreast NeoplasmsCell Line, TumorCurcuminDisease Models, AnimalDisease ProgressionEnzyme InhibitorsFemaleGlucoseGlycogen Synthase Kinase 3 betaHumansHyperglycemiaMiceModels, MolecularAntineoplastic AgentsCurcuminEnzyme InhibitorsGlucoseGlycogen Synthase Kinase 3 betaNF-kappa BPpm1d protein, mouseProtein Phosphatase 2CReactive Oxygen SpeciesTumor Suppressor Protein p53breast cancerdiabetesGSK3βhigh glucoseNF-κBp53PP2Cδ
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.