Evidence map›Paper›PMID 29808701›Full record

ArticleAIDS research and human retroviruses2019

Oral Microbiome in HIV-Infected Women: Shifts in the Abundance of Pathogenic and Beneficial Bacteria Are Associated with Aging, HIV Load, CD4 Count, and Antiretroviral Therapy.

Tyler Lewy, Bo-Young Hong, Barbara Weiser, Harold Burger, Andrew Tremain, George Weinstock, Kathryn Anastos, Michael D George

Abstract read
In one paragraph

Article in AIDS research and human retroviruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 36 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Microbiota of Saliva: A Non-invasive Diagnostic Tool.Indian journal of microbiology · 2024
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Tyler Lewy1 Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, Davis, California.
Bo-Young Hong2 The Jackson Laboratory, Farmington, Connecticut.
Barbara Weiser3 Department of Medicine, Division of Infectious Disease, University of California, Davis, Davis, California.
Harold Burger3 Department of Medicine, Division of Infectious Disease, University of California, Davis, Davis, California.
Andrew Tremain1 Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, Davis, California.
George Weinstock2 The Jackson Laboratory, Farmington, Connecticut.
Kathryn Anastos5 Albert Einstein College of Medicine, Bronx, New York.
Michael D George1 Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, Davis, California.
University of California, Davis · USJackson Laboratory · USUniversity of California Davis Medical Center · USAlbert Einstein College of Medicine · US

Funding

Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
NCATS NIH HHS UL1 TR000004NCATS NIH HHS UL1 TR000454
6 · The paper itself

Abstract

Human immunodeficiency virus (HIV)-associated nonacquired immunodeficiency syndrome (AIDS) conditions, such as cardiovascular disease, diabetes, osteoporosis, and dementia are more prevalent in older than in young adult HIV-infected subjects. Although the oral microbiome has been studied as a window into pathogenesis in aging populations, its relationship to HIV disease progression, opportunistic infections, and HIV-associated non-AIDS conditions is not well understood. We utilized 16S rDNA-based pyrosequencing to compare the salivary microbiome in three groups: (1) Chronically HIV-infected women >50 years of age (aging); (2) HIV-infected women <35 years of age (young adult); and (3) HIV-uninfected age-matched women. We also examined correlations between salivary dysbiosis, plasma HIV RNA, CD4

Indexed as

Gastrointestinal MicrobiomeViral LoadAdultAgingAntiretroviral Therapy, Highly ActiveBacteriaCD4 Lymphocyte CountCD4-Positive T-LymphocytesCohort StudiesDysbiosisFemaleHigh-Throughput Nucleotide SequencingHIVHIV InfectionsHumansMiddle AgedRNA, Ribosomal, 16Sagingdisease progressionHIVopportunistic infectionoral microbiomesaliva

Identifiers

PMID29808701
PMCPMC6909750
OpenAlexW2807282638

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.