ArticleInternational wound journal2018
Diabetic foot infection: A critical complication.
Article in International wound journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.
- Biofilm in Diabetic Foot Ulcers: A Systematic Narrative Review.International wound journal · 2025Pooled it
- [Clinical study of local injection of autologous platelet-rich plasma in treatment of diabetic foot ulcer].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2019Trial
- A Retrospective Study of Infections and Antibiotic Susceptibility in Diabetic Foot Ulcers.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2026Article
- Potential of phage therapy for the treatment of diabetic foot infections.Folia microbiologica · 2026Review
- A longitudinal profiling of microbiome of diabetic foot ulcers shows functional role of microbial communities in wound worsening and chronicity.Current research in microbial sciences · 2026Article
- Neutrophil-Specific Biomarker S100A2 Mediates Diabetic Foot Ulcer Through IL-17 Signaling Pathway and Potential Therapeutics.Journal of inflammation research · 2026Article
- The relationship between urinary albumin-to-creatinine ratio and bacterial profiles/inflammatory markers in diabetic foot infections: a retrospective cross-sectional observational study.Frontiers in endocrinology · 2026Observational
- Review
- Article
- First report on comprehensive genomic analysis of a multidrug-resistant Enterobacter asburiae isolated from diabetic foot infection from Bangladesh.Scientific reports · 2025Article
- Altered expression of miR-132, miR-155, VEGF, and IGF-1 as key indicators in the pathogenesis of diabetic foot infection.American journal of translational research · 2025Article
- Editorial: Diabetic wound: multifaceted mechanisms and future of diabetic wound healing, volume II.Frontiers in endocrinology · 2025Article
- Identifying multidrug-resistant organisms in diabetic foot ulcers: a study of risk factors and antimicrobial resistance genes.World journal of microbiology & biotechnology · 2024Article
- The antimicrobial and antibiofilm effects of gentamicin, imipenem, and fucoidan combinations against dual-species biofilms of Staphylococcus aureus and Acinetobacter baumannii isolated from diabetic foot ulcers.Annals of clinical microbiology and antimicrobials · 2024Article
- Article
- Brazilian Society of Angiology and Vascular Surgery 2023 guidelines on the diabetic foot.Jornal vascular brasileiro · 2024Article
- Validity and reliability of Chinese version of the new diabetic foot ulcer assessment scale.International wound journal · 2023Article
- The impact of wound pH on the antibacterial properties of Medical Grade Honey when applied to bacterial isolates present in common foot and ankle wounds. An in vitro study.Journal of foot and ankle research · 2023Article
- Innovative Functional Biomaterials as Therapeutic Wound Dressings for Chronic Diabetic Foot Ulcers.International journal of molecular sciences · 2023Review
- Defensins ofInternational journal of environmental research and public health · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The number of people in the world with diabetes has nearly quadrupled in the past 40 years. Current data show that 25% of these diabetics will develop a foot ulcer in their lifetime and that the cost of care for a diabetic foot ulcer (DFU) is over twice that of any other chronic ulcer aetiology. Microbial biofilm has been linked to both wound chronicity and infection. Close to 1 in 2 diabetics with a DFU are predicted to go on to develop a diabetic foot infection (DFI). The majority of these DFIs have been found to evolve even before the diabetic individual has received an initial referral for expert DFU management. Of these infected DFUs, less than half have been shown to heal over the next year; many of these individuals will require costly hospitalisation, and current data show that far too many DFIs will require extremity amputation to achieve infection resolution. The development of an infection in a DFU is critical at least in part because paradigms of infection prevention and management are evolving. The effectiveness of our current practice standards is being challenged by a growing body of research related to the prevalence and recalcitrance of the microbes in biofilm to topical and systemic antimicrobials. This article will review the magnitude of current challenges related to DFI prevention and management along with what is currently considered to be standard of care. These ideas will be compared and contrasted with what is known about the biofilm phenotype; then, considerations to support progress towards the development of more cost-effective protocols of care are highlighted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.