Evidence map›Paper›PMID 29808585›Full record

ArticleProteomics. Clinical applications2018

Proteomic Characterization of a New asymmetric Cellulose Triacetate Membrane for Hemodialysis.

Maurizio Ronci, Lidia Leporini, Paolo Felaco, Vittorio Sirolli, Luisa Pieroni, Viviana Greco, Antonio Aceto, Andrea Urbani, Mario Bonomini

Abstract read
PubMed Publisher
In one paragraph

Article in Proteomics. Clinical applications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Effects of the Fluid Replacement Method During Online Hemodiafiltration on the Solute Removal Performance and Biocompatibility Using the Asymmetric Cellulose Triacetate Membrane.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Maurizio RonciDepartment of Medical, Oral and Biotechnological Sciences, University "G. D'Annunzio" of Chieti-Pescara, Chieti 66100, Italy.
Lidia LeporiniDepartment of Pharmacy, University "G. D'Annunzio" of Chieti-Pescara, Chieti 66100, Italy.
Paolo FelacoDepartment of Medicine and Aging Sciences, University "G. D'Annunzio" of Chieti-Pescara, Chieti 66100, Italy.
Vittorio SirolliDepartment of Medicine and Aging Sciences, University "G. D'Annunzio" of Chieti-Pescara, Chieti 66100, Italy.
Luisa PieroniIRCCS-Santa Lucia Foundation, Rome 00144, Italy.
Viviana GrecoIRCCS-Santa Lucia Foundation, Rome 00144, Italy.
Antonio AcetoDepartment of Medical, Oral and Biotechnological Sciences, University "G. D'Annunzio" of Chieti-Pescara, Chieti 66100, Italy.
Andrea UrbaniIRCCS-Santa Lucia Foundation, Rome 00144, Italy.
Mario BonominiDepartment of Medicine and Aging Sciences, University "G. D'Annunzio" of Chieti-Pescara, Chieti 66100, Italy.
University of Chieti-Pescara · ITFondazione Santa Lucia · ITUniversità Cattolica del Sacro Cuore · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe artificial membrane inside the haemodialyzer is the main determinant of the quality and success of haemodialysis therapy. The performances of haemodialysis membranes are highly influenced by the interactions with plasma proteins, which in turn are related to the physical and chemical characteristics of the membrane material. The present cross-over study is aimed to analyse the haemodialysis performance of a newly developed asymmetric cellulose triacetate membrane (ATA) in comparison to the conventional parent symmetric polymer (CTA). EXPERIMENTAL

designIn four chronic non diabetic haemodialysis patients, the protein constituents of the adsorbed material from the filters after the haemodialysis session, and the proteins recovered in the ultrafiltrate during the session, are identified using a bottom-up shotgun proteomics approach.

resultsThe ATA membrane shows a lower protein adsorption rate and a lower mass distribution pattern of the proteinaceous material. CONCLUSIONS AND CLINICAL RELEVANCE: By highlighting the differences between the two haemodialysis filters in terms of adsorbed proteins and flow through, it is demonstrated the higher biocompatibility of the novel ATA membrane, that fulfils the indications for the development of more performant membranes and may represent a step forward for the treatment of patients on chronic haemodialysis.

Indexed as

ProteomicsRenal DialysisAdolescentAdsorptionAdultBlood ProteinsCelluloseCross-Over StudiesFemaleHumansMaleMembranes, ArtificialPolymersYoung AdultBlood ProteinsCellulosecellulose triacetateMembranes, ArtificialPolymersadsorptioncellulose triacetate membranehemodialysisliquid chromatography tandem mass spectrometryprotein identification

Identifiers

PMID29808585
OpenAlexW2807303844

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.