Evidence map›Paper›PMID 29808515›Full record

ArticleTraffic (Copenhagen, Denmark)2018

Dynamic lateral organization of opioid receptors (kappa, mu

Maciej K Rogacki, Ottavia Golfetto, Steven J Tobin, Tianyi Li, Sunetra Biswas, Raphael Jorand, Huiying Zhang, Vlad Radoi, Yu Ming, Per Svenningsson and 7 more

Open access · hybridAbstract read
In one paragraph

Article in Traffic (Copenhagen, Denmark), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Lipid rafts as viral entry routes and immune platforms: A double-edged sword in SARS-CoV-2 infection?Biochimica et biophysica acta. Molecular and cell biology of lipids · 2022
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Spatial encoding of GPCR signaling in the nervous system.Current opinion in cell biology · 2019
    Review
  15. Review
  16. GRK Mediates μ-Opioid Receptor Plasma Membrane Reorganization.Frontiers in molecular neuroscience · 2019
    Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

Maciej K RogackiDepartment of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden.
Ottavia GolfettoDepartment of Molecular Medicine, Beckman Research Institute, City of Hope, Duarte, California.
Steven J TobinDepartment of Molecular Medicine, Beckman Research Institute, City of Hope, Duarte, California.
Tianyi LiDepartment of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden.
Sunetra BiswasDepartment of Molecular Medicine, Beckman Research Institute, City of Hope, Duarte, California.
Raphael JorandDepartment of Molecular Medicine, Beckman Research Institute, City of Hope, Duarte, California.
Huiying ZhangDepartment of Molecular Medicine, Beckman Research Institute, City of Hope, Duarte, California.
Vlad RadoiDepartment of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden.
Yu MingDepartment of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden.
Per SvenningssonDepartment of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden.
Daniel GanjaliDepartment of Mechanical and Aerospace Engineering, The Henry Samueli School of Engineering, University of California, Irvine, California.
Devin L WakefieldDepartment of Molecular Medicine, Beckman Research Institute, City of Hope, Duarte, California.
Athanasios SiderisDepartment of Mechanical and Aerospace Engineering, The Henry Samueli School of Engineering, University of California, Irvine, California.
Alexander R SmallDepartment of Physics and Astronomy, California State Polytechnic University, Pomona, California.
Lars TereniusDepartment of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden.
Tijana Jovanović-TalismanDepartment of Molecular Medicine, Beckman Research Institute, City of Hope, Duarte, California.
Vladana VukojevićDepartment of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-0873-5653
City Of Hope National Medical Center · USKarolinska Institutet · SEUniversity of California, Irvine · USCalifornia State Polytechnic University · USScripps Research Institute · US

Funding

Optimization of multivalent ligands by super-resolution microscopy to treat canceR21CA174608 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI TALISMAN, TIJANA, WILLIAMS, JOHN CHARLES · 2013 to 2015
$650k
NCI NIH HHS R21 CA174608
6 · The paper itself

Abstract

Opioid receptors are important pharmacological targets for the management of numerous medical conditions (eg, severe pain), but they are also the gateway to the development of deleterious side effects (eg, opiate addiction). Opioid receptor signaling cascades are well characterized. However, quantitative information regarding their lateral dynamics and nanoscale organization in the plasma membrane remains limited. Since these dynamic properties are important determinants of receptor function, it is crucial to define them. Herein, the nanoscale lateral dynamics and spatial organization of kappa opioid receptor (KOP), wild type mu opioid receptor (MOP

Indexed as

dynamic lateral organizationfluorescence correlation spectroscopyGPCRnanoscopyopioid receptorpair-correlation photoactivated localization microscopysuper-resolution

Identifiers

PMID29808515
PMCPMC6120469
OpenAlexW2807025364

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.