ArticleEuropean radiology2018
Improved detection rates and treatment planning of head and neck cancer using dual-layer spectral CT.
Article in European radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- The value of dual-layer detector spectral CT multiparameter imaging in distinguishing between benign lesions and carcinomas of the larynx and hypopharynx.Quantitative imaging in medicine and surgery · 2026Article
- Noninvasive stratification of HER2 status in breast cancer using multiparametric DECT: a prospective cohort study.International journal of surgery (London, England) · 2026Article
- Machine learning model incorporating spectral CT quantitative parameters and clinical characteristics for differentiation of benign and malignant thyroid nodules.BMC medical imaging · 2025Article
- The value of machine learning based on spectral CT quantitative parameters in the distinguishing benign from malignant thyroid micro-nodules.BMC cancer · 2025Article
- Synthetic Low-Energy Monochromatic Image Generation in Single-Energy Computed Tomography System Using a Transformer-Based Deep Learning Model.Journal of imaging informatics in medicine · 2024Article
- Impact of scatter radiation on spectral quantification performance of first- and second-generation dual-layer spectral computed tomography.Journal of applied clinical medical physics · 2024Article
- Spectral performance evaluation of a second-generation spectral detector CT.Journal of applied clinical medical physics · 2024Article
- Spectral CT - a new supplementary method for preoperative assessment of pathological grades of esophageal squamous cell carcinoma.BMC medical imaging · 2023Article
- Virtual monoenergetic images by spectral detector computed tomography may improve image quality and diagnostic ability for ischemic lesions in acute ischemic stroke.Acta radiologica (Stockholm, Sweden : 1987) · 2023Article
- Improving radiation physics, tumor visualisation, and treatment quantification in radiotherapy with spectral or dual-energy CT.Journal of applied clinical medical physics · 2022Review
- Dual-Layer Spectral CT Imaging of Upper Aerodigestive Tract Cancer: Analysis of Spectral Imaging Parameters and Impact on Tumor Staging.AJNR. American journal of neuroradiology · 2021Article
- Prediction of Tumor Cellularity in Resectable PDAC from Preoperative Computed Tomography Imaging.Cancers · 2021Article
- Usefulness of dual-layer spectral CT in follow-up examinations: diagnosing recurrent squamous cell carcinomas in the head and neck.Japanese journal of radiology · 2021Article
- Nanoparticle contrast agents for X-ray imaging applications.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2020Review
- CTPA with a conventional CT at 100 kVp vs. a spectral-detector CT at 120 kVp: Comparison of radiation exposure, diagnostic performance and image quality.European journal of radiology open · 2020Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to evaluate the advantages of dual-layer spectral CT (DLSCT) in detection and staging of head and neck cancer (HNC) as well as the imaging of tumour margins and infiltration depth compared to conventional contrast enhanced CT (CECT). MATERIALS AND
methodsThirty-nine patients with a proven diagnosis of HNC were examined with a DLSCT scanner and retrospectively analysed. An age-matched healthy control group of the same size was used. Images were acquired in the venous phase. Virtual monoenergetic 40keV-equivalent (MonoE40) images were compared to CECT-images. Diagnostic confidence for tumour identification and margin detection was rated independently by four experienced observers. The steepness of the Hounsfield unit (HU)-increase at the tumour margin was analysed. External carotid artery branch image reconstructions were performed and their contrast compared to conventional arterial phase imaging. Means were compared using a Student's t-test. ANOVA was used for multiple comparisons.
resultsMonoE40 images were superior to CECT-images in tumour detection and margin delineation. MonoE40 showed significantly higher attenuation differences between tumour and healthy tissue compared to CECT-images (p < 0.001). The HU-increase at the boundary of the tumour was significantly steeper in MonoE40 images compared to CECT-images (p < 0.001). Iodine uptake in the tumour was significantly higher compared to healthy tissue (p < 0.001). MonoE40 compared to conventional images allowed visualisation of external carotid artery branches from the venous phase in a higher number of cases (87% vs. 67%).
conclusionDLSCT enables improved detection of primary and recurrent head and neck cancer and quantification of tumour iodine uptake. Improved contrast of MonoE40 compared to conventional reconstructions enables higher diagnostic confidence concerning tumour margin detection and vessel identification. KEY POINTS: • Sensitivity concerning tumour detection are higher using dual-layer spectral-CT than conventional CT. • Lesion to background contrast in DLSCT is significantly higher than in CECT. • DLSCT provides sufficient contrast for evaluation of external carotid artery branches.
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