Evidence map›Paper›PMID 29808373›Full record

ArticleCytotechnology2018

Cytotoxic, tubulin-interfering and proapoptotic activities of 4'-methylthio-trans-stilbene derivatives, analogues of trans-resveratrol.

Renata Mikstacka, Małgorzata Zielińska-Przyjemska, Zbigniew Dutkiewicz, Michał Cichocki, Tomasz Stefański, Mariusz Kaczmarek, Wanda Baer-Dubowska

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cytotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Renata MikstackaDepartment of Inorganic and Analytical Chemistry, Nicolaus Copernicus University, Ludwik Rydygier Collegium Medicum, Dr A. Jurasza 2, 85-089, Bydgoszcz, Poland. mikstar@cm.umk.pl.
Małgorzata Zielińska-PrzyjemskaDepartment of Pharmaceutical Biochemistry, Poznań University of Medical Sciences, Święcickiego 4, 60-781, Poznań, Poland.
Zbigniew DutkiewiczDepartment of Chemical Technology of Drugs, Poznań University of Medical Sciences, Grunwaldzka 6, 60-780, Poznań, Poland.
Michał CichockiDepartment of Pharmaceutical Biochemistry, Poznań University of Medical Sciences, Święcickiego 4, 60-781, Poznań, Poland.
Tomasz StefańskiDepartment of Chemical Technology of Drugs, Poznań University of Medical Sciences, Grunwaldzka 6, 60-780, Poznań, Poland.
Mariusz KaczmarekDepartment of Clinical Immunology, Poznań University of Medical Sciences, Rokietnicka 5d, 60-806, Poznań, Poland.
Wanda Baer-DubowskaDepartment of Pharmaceutical Biochemistry, Poznań University of Medical Sciences, Święcickiego 4, 60-781, Poznań, Poland.
Poznan University of Medical Sciences · PLCollegium Medicum in Bydgoszcz · PL

Funding

Poznan University of Medical Sciences 502-01-03302403-02524Poznan University of Medical Sciences 502-01-03313427-08870
6 · The paper itself

Abstract

The aim of this study was to evaluate the cytotoxicity of a series of seven 4'-methylthio-trans-stilbene derivatives against cancer cells: MCF7 and A431 in comparison with non-tumorigenic MCF12A and HaCaT cells. The mechanism of anti-proliferative activity of the most cytotoxic trans-resveratrol analogs: 3,4,5-trimethoxy-4'-methylthio-trans-stilbene (3,4,5-MTS) and 2,4,5-trimethoxy-4'-methylthio-trans-stilbene (2,4,5-MTS) was analyzed and compared with the effect of trans-resveratrol. All the compounds that were studied exerted a stronger cytotoxic effect than trans-resveratrol did. MCF7 cells were the most sensitive to the cytotoxic effect of trans-resveratrol analogs with IC

Indexed as

ApoptosisCytotoxicityResveratrolStilbenesTubulin polymerization

Identifiers

PMID29808373
PMCPMC6214853
OpenAlexW2806155824

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.