Evidence map›Paper›PMID 29808345›Full record

Observational studyIntensive care medicine2018

Outcome in patients perceived as receiving excessive care across different ethical climates: a prospective study in 68 intensive care units in Europe and the USA.

D D Benoit, H I Jensen, J Malmgren, V Metaxa, A K Reyners, M Darmon, K Rusinova, D Talmor, A P Meert, L Cancelliere and 13 more

2 registry-linked trialsOpen access · hybridAbstract readObservational Study
In one paragraph

Observational study in Intensive care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 51 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 3 pooled it
27.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05167019 nacompletednot on this mapstarted 2022, after this paper: background citation

Coaching Doctors to Improve Ethical Decision-making in Adult Hospitalized Patients Potentially Receiving Excessive Treatment: a Step Wedge Cluster Randomized Trial in 10 Departments of the Ghent University Hospital (CODE)

TypeinterventionalSponsorUniversity Hospital, GhentRan2022 to 2024Enrolled125ConditionsEnd of Life, Interdisciplinary Communication, LeadershipArmsCODE intervention, Usual care
NCT07327450 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Coaching Doctors and Nurses to Improve Ethical Decision-making in Team: a Stepped Wedge Cluster Randomized Trial in 10 Departments of the Ghent University Hospital

TypeinterventionalSponsorUniversity Hospital, GhentRan2026 to 2028Enrolled360ConditionsDecision Making ,Shared, Leadership, End of Life Communication, End of Life Decision MakingArmsUsual Care Group, CODE II intervention
3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 3 syntheses or guidelines pooled it, 134 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Article
  8. Article
  9. Review
  10. Article
  11. [S1 guideline on sustainability in intensive care and emergency medicine].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025
    Review
  12. Article
  13. Observational
  14. Article
  15. [Intensive care and emergency medicine overuse and sustainability].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025
    Review
  16. Article
  17. Article
  18. Indian Society of Critical Care Medicine and Indian Association of Palliative Care Expert Consensus and Position Statements for End-of-life and Palliative Care in the Intensive Care Unit.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024
    Article
  19. Observational
  20. Simplified Legal Procedure for End-of-life Decisions in India: A New Dawn in the Care of the Dying?Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 11 institutions in 11 countries.

D D BenoitDepartment of Intensive Care Medicine, Ghent University Hospital, Corneel Heymanslaan 10, Ghent, Belgium. dominique.benoit@ugent.be.ORCID http://orcid.org/0000-0002-0227-5169
H I JensenDepartment of Intensive Care Medicine, Vejle Hospital, Vejle, Denmark.
J MalmgrenDepartment of Anaesthesiology and Intensive Care, Sahlgrenska University Hospital, Gothenburg, Sweden.
V MetaxaKing's College Hospital, London, UK.
A K ReynersDepartment of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
M DarmonHôpital Saint-Louis and University, Paris-7, Paris, France.
K RusinovaDepartment of Anesthesiology and Intensive Care, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic.
D TalmorDepartment of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
A P MeertService des soins intensifs et urgences oncologiques, Institut Jules Bordet, ULB, Brussels, Belgium.
L CancelliereSCDU Anestesia e Rianimazione, Azienda and Ospedaliero Universitaria, "Maggiore della Carità", Novara, Italy.
L ZubekSemmelweis University Budapest, Budapest, Hungary.
P MaiaIntensive Care Department, Hospital S.António, Porto, Portugal.
A MichalsenTettnang Hospital, Tettnang, Germany.
S VanheuleDepartment of Psycho-analysis and Clinical Consulting, Faculty of Psychology and Educational Sciences, Ghent University, Ghent, Belgium.
E J O KompanjeDepartment of Intensive Care Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
J DecruyenaereDepartment of Intensive Care Medicine, Ghent University Hospital, Corneel Heymanslaan 10, Ghent, Belgium.
S VandenbergheDepartment of Applied Mathematics, Computer Science and Statistics, Faculty of Sciences, Ghent University, Ghent, Belgium.
S VansteelandtDepartment of Applied Mathematics, Computer Science and Statistics, Faculty of Sciences, Ghent University, Ghent, Belgium.
B GadeyneDepartment of Intensive Care Medicine, Ghent University Hospital, Corneel Heymanslaan 10, Ghent, Belgium.
B Van den BulckeDepartment of Intensive Care Medicine, Ghent University Hospital, Corneel Heymanslaan 10, Ghent, Belgium.
E AzoulayHôpital Saint-Louis and University, Paris-7, Paris, France.
R D PiersDepartment of Geriatric Medicine, Ghent University Hospital, Ghent, Belgium.
DISPROPRICUS study group of the Ethics Section of the European Society of Intensive Care Medicine
Ghent University Hospital · BEBeth Israel Deaconess Medical Center · USGhent University · BESemmelweis University · HUUniversity Medical Center Groningen · NLCharles University · CZErasmus MC · NLHospital de Santo António · PTSahlgrenska University Hospital · SEUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITUniversity of Southern Denmark · DK

Funding

ESICM/ECCRN Clinical research awardFWO 1800513N
6 · The paper itself

Abstract

purposeWhether the quality of the ethical climate in the intensive care unit (ICU) improves the identification of patients receiving excessive care and affects patient outcomes is unknown.

methodsIn this prospective observational study, perceptions of excessive care (PECs) by clinicians working in 68 ICUs in Europe and the USA were collected daily during a 28-day period. The quality of the ethical climate in the ICUs was assessed via a validated questionnaire. We compared the combined endpoint (death, not at home or poor quality of life at 1 year) of patients with PECs and the time from PECs until written treatment-limitation decisions (TLDs) and death across the four climates defined via cluster analysis.

resultsOf the 4747 eligible clinicians, 2992 (63%) evaluated the ethical climate in their ICU. Of the 321 and 623 patients not admitted for monitoring only in ICUs with a good (n = 12, 18%) and poor (n = 24, 35%) climate, 36 (11%) and 74 (12%), respectively were identified with PECs by at least two clinicians. Of the 35 and 71 identified patients with an available combined endpoint, 100% (95% CI 90.0-1.00) and 85.9% (75.4-92.0) (P = 0.02) attained that endpoint. The risk of death (HR 1.88, 95% CI 1.20-2.92) or receiving a written TLD (HR 2.32, CI 1.11-4.85) in patients with PECs by at least two clinicians was higher in ICUs with a good climate than in those with a poor one. The differences between ICUs with an average climate, with (n = 12, 18%) or without (n = 20, 29%) nursing involvement at the end of life, and ICUs with a poor climate were less obvious but still in favour of the former.

conclusionEnhancing the quality of the ethical climate in the ICU may improve both the identification of patients receiving excessive care and the decision-making process at the end of life.

Indexed as

Intensive Care UnitsOrganizational CultureQuality of LifeUnnecessary ProceduresAge FactorsEuropeHumansProspective StudiesDecision-makingEthical climateInterdisciplinary collaborationPatient outcomesPerceived excessive careTreatment-limitation decisions

Identifiers

PMID29808345
PMCPMC6061457
OpenAlexW2806505892

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.