Evidence map›Paper›PMID 29808317›Full record

ArticleJournal of cancer research and clinical oncology2018

TIS21

Santhoshkumar Sundaramoorthy, Preethi Devanand, Min Sook Ryu, Kye Yong Song, Dong Young Noh, In Kyoung Lim

Open access · greenAbstract read
In one paragraph

Article in Journal of cancer research and clinical oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Impact of Duration of Neoadjuvant Aromatase Inhibitors on Molecular Expression Profiles in Estrogen Receptor-positive Breast Cancers.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
    Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Santhoshkumar SundaramoorthyDivision of Medical Sciences, BK21 Plus program, Graduate School of Ajou University, Suwon, 16499, Republic of Korea.
Preethi DevanandDivision of Medical Sciences, BK21 Plus program, Graduate School of Ajou University, Suwon, 16499, Republic of Korea.
Min Sook RyuDivision of Medical Sciences, BK21 Plus program, Graduate School of Ajou University, Suwon, 16499, Republic of Korea.
Kye Yong SongDepartment of Pathology, Chung-Ang University College of Medicine, Seoul, 156-756, Republic of Korea.
Dong Young NohDepartment of Surgery, Seoul National University, Seoul, 03080, Republic of Korea.
In Kyoung LimDivision of Medical Sciences, BK21 Plus program, Graduate School of Ajou University, Suwon, 16499, Republic of Korea. iklim@ajou.ac.kr.ORCID http://orcid.org/0000-0002-2399-607X
Ajou University · KRChung-Ang University · KRSeoul National University · KR

Funding

National Research Foundation of Korea 2016R1A2B4006466
6 · The paper itself

Abstract

purposeIt has been reported that PI3K/AKT pathway is altered in various cancers and AKT isoforms specifically regulate cell growth and metastasis of cancer cells; AKT1, but not AKT2, reduces invasion of cancer cells but maintains cancer growth. We propose here a novel mechanism of the tumor suppresser, TIS21

methodsTransduction of adenovirus carrying TIS21

resultsWe observed that TIS21

conclusionsTIS21

Indexed as

AnimalsBreast NeoplasmsCell Growth ProcessesFemaleHumansImmediate-Early ProteinsMCF-7 CellsMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2MiceMice, Inbred C57BLMice, KnockoutNFATC Transcription FactorsPhosphoprotein PhosphatasesSignal TransductionSirolimusBTG2 protein, humanBtg2 protein, mouseImmediate-Early ProteinsMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2NFATC2 protein, humanNfatc2 protein, mouseNFATC Transcription FactorsPHLPP2 protein, humanPHLPP2 protein, mousePhosphoprotein PhosphatasesSirolimusTumor Suppressor ProteinsAKT1mTORc1, mTORc2NFAT1PHLPP2TIS21/BTG2Triple negative breast cancer

Identifiers

PMID29808317
PMCPMC11813427
OpenAlexW2806240892

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.