ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2018
Prediction of insufficient serum vitamin D status in older women: a validated model.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prediction models and questionnaires developed to predict vitamin D status in adults: a systematic review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Pooled it
- Article
- Compliance with the Netherlands' vitamin D supplementation recommendation for three at-risk groups: young children, women over 50 years, and elderly.European journal of nutrition · 2026Article
- Vitamin D status of adults in the North of the Netherlands: cross-sectional results from the Lifelines cohort study.European journal of clinical nutrition · 2025Article
- Development and validation of prediction model for vitamin D deficiency in Chinese college students (a dynamic online nomogram predicting vitamin D deficiency for Chinese college students).Journal of health, population, and nutrition · 2025Article
- Simple prediction model for vitamin D deficiency in women with osteoporosis or risk factors for osteoporosis in Thailand.Journal of clinical & translational endocrinology · 2024Article
- Development of a predictive scoring system for vitamin D deficiency 'Vitamin D Deficiency Predicting Scoring (ViDDPreS)' based on the vitamin D status in young Japanese women: a nationwide cross-sectional study.Public health nutrition · 2024Article
- The yield of routine laboratory examination in osteoporosis evaluation in primary care.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Article
- Forecasting levels of serum 25-hydroxyvitamin D based on dietary intake, lifestyle and personal determinants in a sample of Southern Europeans.The British journal of nutrition · 2023Article
- Score-based prediction model for severe vitamin D deficiency in patients with critical illness: development and validation.Critical care (London, England) · 2022Article
- Role of vitamin D supplementation in the management of musculoskeletal diseases: update from an European Society of Clinical and Economical Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) working group.Aging clinical and experimental research · 2022Review
- Review
- Development and Validation of a Predictive Model of Hypovitaminosis D in General Adult Population: SCOPYD Study.Nutrients · 2021Article
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Abstract
We developed an externally validated simple prediction model to predict serum 25(OH)D levels < 30, < 40, < 50 and 60 nmol/L in older women with risk factors for fractures. The benefit of the model reduces when a higher 25(OH)D threshold is chosen.
introductionVitamin D deficiency is associated with increased fracture risk in older persons. General supplementation of all older women with vitamin D could cause medicalization and costs. We developed a clinical model to identify insufficient serum 25-hydroxyvitamin D (25(OH)D) status in older women at risk for fractures.
methodsIn a sample of 2689 women ≥ 65 years selected from general practices, with at least one risk factor for fractures, a questionnaire was administered and serum 25(OH)D was measured. Multivariable logistic regression models with backward selection were developed to select predictors for insufficient serum 25(OH)D status, using separate thresholds 30, 40, 50 and 60 nmol/L. Internal and external model validations were performed.
resultsPredictors in the models were as follows: age, BMI, vitamin D supplementation, multivitamin supplementation, calcium supplementation, daily use of margarine, fatty fish ≥ 2×/week, ≥ 1 hours/day outdoors in summer, season of blood sampling, the use of a walking aid and smoking. The AUC was 0.77 for the model using a 30 nmol/L threshold and decreased in the models with higher thresholds to 0.72 for 60 nmol/L. We demonstrate that the model can help to distinguish patients with or without insufficient serum 25(OH)D levels at thresholds of 30 and 40 nmol/L, but not when a threshold of 50 nmol/L is demanded.
conclusionsThis externally validated model can predict the presence of vitamin D insufficiency in women at risk for fractures. The potential clinical benefit of this tool is highly dependent of the chosen 25(OH)D threshold and decreases when a higher threshold is used.
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