ArticleNPJ schizophrenia2018
Impairment in delay discounting in schizophrenia and schizoaffective disorder but not primary mood disorders.
Article in NPJ schizophrenia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A multinational analysis of how emotions relate to economic decisions regarding time or risk.Nature human behaviour · 2024Pooled it
- Delay Discounting as a Transdiagnostic Process in Psychiatric Disorders: A Meta-analysis.JAMA psychiatry · 2019Pooled it
- Delay discounting correlates with depression but does not predict relapse after antidepressant discontinuation.Molecular psychiatry · 2026Article
- Impulsivity is associated with suicide attempt in mood disorders with complex moderation by diagnosis and subjective social status.Research square · 2026Article
- Optogenetic inhibition reveals distinct contributions of medial prefrontal cortex to intertemporal choice in young and aged rats.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Reward magnitude-specific delay discounting differentiates mania versus depression risk.Cognitive, affective & behavioral neuroscience · 2025Article
- The Relationship Between Schizotypal Personality Traits and Temporal Discounting: The Role of the Date/Delay Effect.Schizophrenia bulletin · 2025Article
- Decision-making under stress: A psychological and neurobiological integrative model.Brain, behavior, & immunity - health · 2024Article
- Association of temporal discounting with transdiagnostic symptom dimensions.Npj mental health research · 2024Article
- Why now and not later? An exploration into the neurocognitive correlates of delay discounting in bipolar disorder.Psychiatry research communications · 2023Article
- Pharmacological Modulation of Temporal Discounting: A Systematic Review.Healthcare (Basel, Switzerland) · 2023Review
- Cognitive biases as an adaptive strategy in autism and schizophrenia spectrum: the compensation perspective on neurodiversity.Frontiers in psychiatry · 2023Review
- Impaired risk avoidance in bipolar disorder and substance use disorders.Journal of psychiatric research · 2022Article
- Neurobehavioral and neurodevelopmental profiles of a heuristic genetic model of differential schizophrenia- and addiction-relevant features: The RHA vs. RLA rats.Neuroscience and biobehavioral reviews · 2021Review
- Meta-Analysis on the Effect of Contingency Management for Patients with Both Psychotic Disorders and Substance Use Disorders.Journal of clinical medicine · 2021Review
- Delay discounting abnormalities are seen in first-episode schizophrenia but not in bipolar disorder.Schizophrenia research · 2020Article
- Risk tolerance measured by probability discounting among individuals with primary mood and psychotic disorders.Neuropsychology · 2019Article
- Temporal and Effort cost Decision-making in Healthy Individuals with Subclinical Psychotic Symptoms.Scientific reports · 2019Article
- A Genetic Model of Impulsivity, Vulnerability to Drug Abuse and Schizophrenia-Relevant Symptoms With Translational Potential: The Roman High- vs. Low-Avoidance Rats.Frontiers in behavioral neuroscience · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
A measure of planning and impulse control, the delay-discounting (DD) task estimates the extent to which an individual decreases the perceived value of a reward as the reward is delayed. We examined cross-disorder performance between healthy controls (n = 88), individuals with bipolar disorder (n = 23), major depressive disorder (n = 43), and primary psychotic disorders (schizophrenia and schizoaffective disorder; n = 51) on the DD task (using a $10 delayed larger reward), as well as the interaction of DD scores with other symptom domains (cognition, psychosis, and affect). We found that individuals with schizophrenia and schizoaffective disorder display significantly greater rates of discounting compared to healthy controls, while individuals with a primary mood disorder do not differ from healthy controls after adjustment for IQ. Further, impairment in working memory is associated with higher discounting rates among individuals with schizophrenia and schizoaffective disorder, but cognitive dysfunction alone does not account for the extent of impairment in DD. Taken together, these results suggest an impaired ability to plan for the future and make adaptive decisions that are specific to individuals with psychotic disorders, and likely related to adverse functional outcomes. More generally, this work demonstrates the presence of variation in impulsivity across major psychiatric illnesses, supporting the use of a trans-diagnostic perspective.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.