Evidence map›Paper›PMID 29807983›Full record

ArticlePediatric research2018

Mannose-binding lectin and mannose-binding protein-associated serine protease 2 levels and infection in very-low-birth-weight infants.

Annika Hartz, Lena Schreiter, Julia Pagel, Katja Moser, Christian Wieg, Anneke Grotheer, Jan Rupp, Egbert Herting, Wolfgang Göpel, Christoph Härtel

Open access · bronzeAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Pediatric research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Annika HartzThe Department of Pediatrics, The University Hospital Lübeck, Lübeck, Germany. Annika.Hartz@uksh.de.
Lena SchreiterThe Department of Pediatrics, The University Hospital Lübeck, Lübeck, Germany.
Julia PagelThe Department of Pediatrics, The University Hospital Lübeck, Lübeck, Germany.
Katja MoserChildren's Hospital Aschaffenburg-Alzenau, Aschaffenburg, Germany.
Christian WiegChildren's Hospital Aschaffenburg-Alzenau, Aschaffenburg, Germany.
Anneke GrotheerThe Department of Pediatrics, The University Hospital Lübeck, Lübeck, Germany.
Jan RuppThe Department for Clinical Infectious Diseases and Microbiology, The University Hospital Lübeck, Lübeck, Germany.
Egbert HertingThe Department of Pediatrics, The University Hospital Lübeck, Lübeck, Germany.
Wolfgang GöpelThe Department of Pediatrics, The University Hospital Lübeck, Lübeck, Germany.
Christoph HärtelThe Department of Pediatrics, The University Hospital Lübeck, Lübeck, Germany.
University of Lübeck · DEKlinikum Aschaffenburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study was to explore the role of the lectin pathway in neonatal sepsis through the study of MBL and MASP2 levels and their relationship with infection in a cohort of very-low-birth-weight infants (VLBWI).

methodsMBL and MASP2 were measured in plasma samples of n = 89 VLBWI using ELISA and correlated with clinical parameters. MBL plasma levels were aligned with genotyping data of mbl2 exon 1 polymorphisms, rs1800450, rs1800451, and rs5030737.

resultsMBL levels were clearly determined by MBL genotype, i.e., AA individuals had tenfold higher MBL levels than AO individuals. MBL and MASP2 levels did not correlate with gestational age, apart from MASP2 levels on day 7. During the first 21 days of life, we noted a gradual increase in both MBL and MASP2 levels. On day 7 of life, MASP2 levels in infants developing late-onset sepsis measured before the onset of symptoms were found to be lower, as compared to non-LOS infants.

conclusionsIn our cohort of VLBWI, MBL levels were genetically determined, but not associated with gestational age or sepsis in the first 21 days of life. Lower MASP2 levels on day 7 may indicate increased risk for late-onset infection.

Indexed as

Infant, Very Low Birth WeightBirth WeightExonsFemaleGenetic Predisposition to DiseaseGenotypeGestational AgeHumansInfant, NewbornMaleMannose-Binding LectinMannose-Binding Protein-Associated Serine ProteasesPolymorphism, GeneticPolymorphism, Single NucleotidePremature BirthProspective StudiesMannose-Binding LectinMannose-Binding Protein-Associated Serine ProteasesMASP2 protein, humanMBL2 protein, human

Identifiers

PMID29807983
OpenAlexW2804502403

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.