ArticleCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2018
Quadrivalent human papillomavirus vaccination in girls and the risk of autoimmune disorders: the Ontario Grade 8 HPV Vaccine Cohort Study.
Article in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Moving from nature to nurture: a systematic review and meta-analysis of environmental factors associated with juvenile idiopathic arthritis.Rheumatology (Oxford, England) · 2022Pooled it
- Benefits and harms of the human papillomavirus (HPV) vaccines: systematic review with meta-analyses of trial data from clinical study reports.Systematic reviews · 2020Pooled it
- Vaccines for Autoimmune Diseases: Stopping Triggers, Restoring BalanceA Systematic Review with Qualitative Synthesis.Mediterranean journal of rheumatology · 2026Review
- Effectiveness, immunogenicity and safety of human papillomavirus vaccination in non-HIV immunocompromised individuals: a systematic review.EClinicalMedicine · 2026Article
- The Role and Safety of Aluminum Adjuvants in Childhood Vaccines.Pediatrics · 2026Review
- Overcoming HPV Vaccine Hesitancy in Japan: A Narrative Review of Safety Evidence, Risk Communication, and Policy Approaches.Vaccines · 2025Review
- Association Between Human Papillomavirus Vaccination and the Risk of Hashimoto's Thyroiditis: A Cross-Sectional Study.Vaccines · 2025Article
- Article
- Case report: Satralizumab therapy for bilateral refractory optic neuritis following the first dose of bivalent human papilloma virus vaccine.Frontiers in immunology · 2024Article
- Association between vaccination and the risk of central demyelination: results from a case-referent study.Journal of neurology · 2023Article
- Graves' orbitopathy post-SARS-CoV-2 vaccines: report on six patients.Journal of endocrinological investigation · 2023Article
- The effect of the BNT162b2 vaccine on antinuclear antibody and antiphospholipid antibody levels.Immunologic research · 2022Article
- Article
- New-onset Graves' disease following SARS-CoV-2 vaccination: a case report.European thyroid journal · 2022Article
- Human papillomavirus vaccination and all-cause morbidity in adolescent girls: a cohort study of absence from school due to illness.International journal of epidemiology · 2021Article
- Recurrence of Graves' Disease (a Th1-type Cytokine Disease) Following SARS-CoV-2 mRNA Vaccine Administration: A Simple Coincidence?European journal of case reports in internal medicine · 2021Article
- Prospective data linkage to facilitate COVID-19 trials - A call to action.International journal of population data science · 2020Article
- Human papillomavirus (HPV) vaccine and autonomic disorders: a position statement from the American Autonomic Society.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020Review
- Addressing HPV vaccine myths: practical information for healthcare providers.Human vaccines & immunotherapeutics · 2019Review
- Human Vaccines & Immunotherapeutics: News.Human vaccines & immunotherapeutics · 2018Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDespite demonstrated effectiveness in real-world settings, concerns persist regarding the safety of the quadrivalent human papillomavirus (HPV4) vaccine. We sought to assess the risk of autoimmune disorders following HPV4 vaccination among grade 8 girls eligible for Ontario's school-based HPV vaccination program.
methodsWe undertook a population-based retrospective cohort study using Ontario's administrative health and vaccination databases from 2007 to 2013. The self-controlled case series method was used to compare the rate of a composite end point of autoimmune disorders diagnosed during days 7-60 post-vaccination ("exposed" follow-up) to that at any other time ("unexposed"). The analysis was repeated to assess the effect of a history of immune-mediated diseases and time since vaccination. We also conducted an exploratory analysis of individual autoimmune disorders. Rate ratios and 95% confidence intervals (CIs) were estimated using conditional Poisson regression, adjusted for age, seasonality, concomitant vaccinations and infections.
resultsThe study cohort consisted of 290 939 girls aged 12-17 years who were eligible for vaccination between 2007 and 2013. There was no significant risk for developing an autoimmune disorder following HPV4 vaccination (
interpretationWe did not observe an increased risk of autoimmune disorders following HPV4 vaccination among teenaged girls. These findings should reassure parents and health care providers.
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Registered trials
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