Evidence map›Paper›PMID 29807554›Full record

ArticlePsychological medicine2019

Effects of slow-wave activity on mood disturbance in major depressive disorder.

Jennifer R Goldschmied, Philip Cheng, Robert Hoffmann, Elaine M Boland, Patricia J Deldin, Roseanne Armitage

Abstract read
In one paragraph

Article in Psychological medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
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  3. Observational
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  7. From trenches to technology: a narrative review of sleep medicine in the military.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Jennifer R GoldschmiedCenter for Sleep & Circadian Neurobiology, University of Pennsylvania,125 S.31st St, Philadelphia, PA 19104,USA.
Philip ChengSleep Disorders and Research Center, Henry Ford Health System,39450 W 12 Mile Rd, Novi MI 48377,USA.
Robert HoffmannDepartment of Psychiatry,University of Michigan,4250 Plymouth Rd, Ann Arbor, MI 48109,USA.
Elaine M BolandBehavioral Health Service,Cpl. Michael J. Crescenz VA Medical Center,3900 Woodland Ave., Philadelphia, PA 19104,USA.
Patricia J DeldinDepartment of Psychiatry,University of Michigan,4250 Plymouth Rd, Ann Arbor, MI 48109,USA.
Roseanne ArmitageDepartment of Psychiatry,University of Michigan,4250 Plymouth Rd, Ann Arbor, MI 48109,USA.
University of Michigan–Ann Arbor · USHenry Ford Health System · USPhiladelphia VA Medical Center · USUniversity of Pennsylvania · US

Funding

TRAINING PROGRAM/RESPIRATORY NEUROBIOLOGY AND SLEEPT32HL007713 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI PACK, ALLAN I · 1992 to 2022
$11.9M
SEX DIFFERENCES IN SLEEP REGULATION IN DEPRESSIONR01MH061515 · NIMH · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI ARMITAGE, ROSEANNE · 2001 to 2005
$2.1M
Clinical translation of phenotypes of shift work disorderK23HL138166 · NHLBI · HENRY FORD HEALTH SYSTEM · PI CHENG, PHILIP · 2017 to 2021
$761k
The Role of Effort Discounting in the Link between Insomnia and DepressionIK2CX001501 · VA · PHILADELPHIA VA MEDICAL CENTER · PI BOLAND, ELAINE M · 2017 to 2022
–
CSRD VA IK2 CX001501NHLBI NIH HHS K23 HL138166NHLBI NIH HHS T32 HL007713NIMH NIH HHS R01 MH061515
6 · The paper itself

Abstract

backgroundStudies have demonstrated that decreases in slow-wave activity (SWA) predict decreases in depressive symptoms in those with major depressive disorder (MDD), suggesting that there may be a link between SWA and mood. The aim of the present study was to determine if the consequent change in SWA regulation following a mild homeostatic sleep challenge would predict mood disturbance.

methodsThirty-seven depressed and fifty-nine healthy adults spent three consecutive nights in the sleep laboratory. On the third night, bedtime was delayed by 3 h, as this procedure has been shown to provoke SWA. The Profile of Mood States questionnaire was administered on the morning following the baseline and sleep delay nights to measure mood disturbance.

resultsResults revealed that following sleep delay, a lower delta sleep ratio, indicative of inadequate dissipation of SWA from the first to the second non-rapid eye movement period, predicted increased mood disturbance in only those with MDD.

conclusionsThese data demonstrate that in the first half of the night, individuals with MDD who have less SWA dissipation as a consequence of impaired SWA regulation have greater mood disturbance, and may suggest that appropriate homeostatic regulation of sleep is an important factor in the disorder.

Indexed as

AffectSleep, Slow-WaveAdultCase-Control StudiesElectroencephalographyFemaleHumansMajor Depressive DisorderMalePolysomnographyPsychiatric Status Rating ScalesSurveys and QuestionnairesYoung AdultMajor depressive disordermoodsleepslow-wave activitysynaptic downscalingsynaptic strength

Identifiers

PMID29807554
PMCPMC6472262
OpenAlexW2805373503

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.