ArticleJournal of feline medicine and surgery2019
Thrombolysis with tissue plasminogen activator (TPA) in feline acute aortic thromboembolism: a retrospective study of 16 cases.
Article in Journal of feline medicine and surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
- Multicentre aortic thromboembolism thrombolysis evaluation in a retrospective study of 183 cats: the MATTERS study.Frontiers in veterinary science · 2026Article
- Treatment and Prevention of Cardiogenic Arterial Thromboembolism in the Cat: A Systematic Review.Animals : an open access journal from MDPI · 2025Review
- Clinical-Diagnostic and Therapeutic Advances in Feline Hypertrophic Cardiomyopathy.Veterinary sciences · 2025Review
- Use of alteplase continuous rate infusion, pentoxifylline, and cyproheptadine in association or not, in acute feline aortic thromboembolism: a study of nine cats.Frontiers in veterinary science · 2025Article
- Feline Aortic Thromboembolism: Recent advances and future prospects.Journal of feline medicine and surgery · 2024Review
- Circulating neutrophil extracellular traps in cats with hypertrophic cardiomyopathy and cardiogenic arterial thromboembolism.Journal of veterinary internal medicine · 2023Article
- Ultrasonographic findings of feline aortic thromboembolism.Journal of feline medicine and surgery · 2022Article
- Bilateral lysis of aortic saddle thrombus with early tissue plasminogen activator (BLASTT): a prospective, randomized, placebo-controlled study in feline acute aortic thromboembolism.Journal of feline medicine and surgery · 2022Article
- Retrospective Evaluation of Intravenous Enoxaparin Administration in Feline Arterial Thromboembolism.Animals : an open access journal from MDPI · 2022Article
- 2022 Update of the Consensus on the Rational Use of Antithrombotics and Thrombolytics in Veterinary Critical Care (CURATIVE) Domain 6: Defining rational use of thrombolytics.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) · 2022Article
- Neutrophil extracellular traps in feline cardiogenic arterial thrombi: a pilot study.Journal of feline medicine and surgery · 2022Article
- The Feline Cardiomyopathies: 1. General concepts.Journal of feline medicine and surgery · 2021Article
- Pulmonary Sarcomatoid Carcinoma Associated with Arterial Thromboembolism in a Cat.Case reports in veterinary medicine · 2021Article
- Case Report: Non-traumatic Unilateral Forelimb Arterial Thrombosis Associated With Hyperadrenocorticism in a Dog.Frontiers in veterinary science · 2021Article
- Outcome and treatments of dogs with aortic thrombosis: 100 cases (1997-2014).Journal of veterinary internal medicine · 2020Article
- ACVIM consensus statement guidelines for the classification, diagnosis, and management of cardiomyopathies in cats.Journal of veterinary internal medicine · 2020Article
- Viscoelastic coagulation monitoring parameters in cats with acute arterial thromboembolism.Journal of veterinary internal medicineArticle
- Tongue infarction in suspected lingual artery thromboembolism in a cat with hypertrophic cardiomyopathy.JFMS open reportsArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThrombolytic therapy is a treatment of choice for people with acute ischemic events, but is uncommonly administered for feline aortic thromboembolism (FATE). This study reports selected clinical data and outcomes of acute FATE treated with tissue plasminogen activator (TPA). A reference group treated with current standard of care (SOC) was analyzed for comparison.
methodsThis was a retrospective study of FATE in two academic hospitals. TPA-treated cats with two or more limbs (n = 16) affected were compared with a SOC-treated group with two or more limbs affected (n = 38). A limb score based on motor function and pulse quality was calculated for each group.
resultsLimb score and proportion of congestive heart failure at admission was similar in both groups. Time from FATE to admission was shorter in the TPA group, with a median of 3 h (range 0-6 h) vs 6 h (range 0-48 h; P = 0.0004). The most common regimen received for TPA was 1 mg/kg over 1 h. Other treatments were similar to those of the SOC group and included analgesia, thromboprophylaxis and furosemide. Documented complications for TPA-treated cats included reperfusion injury (5/10) and acute kidney injury (AKI; 3/10). Discharge proportion rate was 44% (TPA) vs 29% (SOC; P = 0.351). There were no differences in short-term survival rate (56.2% vs 39.5%; P = 0.369), clinical improvement (56.2% vs 31%; P = 0.122), rates of reperfusion injury (50% vs 50%; P = 1.00) or AKI (30% vs 27%; P = 1.00) between the TPA-treated and SOC groups, respectively. CONCLUSIONS AND RELEVANCE: Survival and complication rates of TPA-treated cats and SOC-treated cats for acute FATE were similar.
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