Evidence map›Paper›PMID 29807258›Full record

ArticleStem cell research2018

Inverse agonism of retinoic acid receptors directs epiblast cells into the paraxial mesoderm lineage.

Ryan P Russell, Yu Fu, Yaling Liu, Peter Maye

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ryan P RussellDepartment of Reconstructive Sciences, School of Dental Medicine, University of Connecticut Health Center, United States.
Yu FuDepartment of Reconstructive Sciences, School of Dental Medicine, University of Connecticut Health Center, United States.
Yaling LiuDepartment of Reconstructive Sciences, School of Dental Medicine, University of Connecticut Health Center, United States.
Peter MayeDepartment of Reconstructive Sciences, School of Dental Medicine, University of Connecticut Health Center, United States. Electronic address: pmaye@uchc.edu.
UConn Health · US

Funding

Skeletal, Craniofacial and Oral Biology Training GrantT90DE021989 · NIDCR · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI MINA, MINA · 2011 to 2022
$4.5M
Embryonic Stem Cell Models to Study the Axial Skeletal LineageR21AR056391 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI MAYE, PETER · 2009 to 2010
$378k
NIAMS NIH HHS R21 AR056391NIDCR NIH HHS T90 DE021989
6 · The paper itself

Abstract

We have investigated the differentiation of paraxial mesoderm from mouse embryonic stem cells utilizing a Tbx6-EYFP/Brachyury (T)-Cherry dual reporter system. Differentiation from the mouse ESC state directly into mesoderm via Wnt pathway activation was low, but augmented by treatment with AGN193109, a pan-retinoic acid receptor inverse agonist. After five days of differentiation, T

Indexed as

AnimalsCell DifferentiationEmbryonic Stem CellsGerm LayersHumansMesodermMiceReceptors, Retinoic AcidReceptors, Retinoic AcidAxial skeletonEmbryonic stem cellEpiblastParaxial mesodermRetinoic acid

Identifiers

PMID29807258
PMCPMC6083448
OpenAlexW2804314332

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.